Research Associate in Neuroscience

Yale University
New Haven County, CT
Sep 12, 2021
Sep 15, 2021
Organization Type
Essential Duties
  1. Recommends the design and implementation of procedures and protocols under the direction of a higher-level authority. 2. Investigates, analyzes, and reaches preliminary scientific conclusions related to research planning 3. Ensures data results are compiled, analyzed, and presented properly. 4. Analyzes, develops and interprets scientific results. Maintains clear documentation of results. Prepares scientific reports and papers for research proposals and published reports. 5. Performs independent research and laboratory techniques and participates in experimental research planning. 6. Interacts with internal contacts including the PI, research assistants, graduate students, Radiation Safety and Biological Safety officers, and Animal Care personnel to discuss and evaluate research results and to ensure the smooth and safe operation of the laboratory. 7. Interacts with external contacts such as researchers at other institutions, staff at biotechnology and reagents companies to consult on research methods and to keep abreast of product information and developments. 8. May perform other duties as assigned.

Required Education and Experience

Master's Degree in a scientific discipline and one year experience or an equivalent combination of education and experience.

Background Check Requirements

All candidates for employment will be subject to pre-employment background screening for this position, which may include motor vehicle, DOT certification, drug testing and credit checks based on the position description and job requirements. All offers are contingent upon the successful completion of the background check. Please visit for additional information on the background check requirements and process.

Position Focus:

The Research Associate will assist a large research lab in the generation and maintenance of a modest colony of mutant mice strains. Will be responsible for the coordination of breeding, genotyping, coordinating shipping/receiving and ongoing maintenance and inventory of colonies. Keep updated computer-based records and compliance documents. Will also maintain molecular biology inventory.

Oversee the daily operation and support of an animal unit. Coordinate breeding and production of mutant mice for lab members. Ensure prompt and continual arrival of stock and special order animals.

Perform weaning, tail docking and numbering of mice. Perform routine genotyping by PCR analysis and/or prepare and ship mouse tissue samples for genotype outsourcing. Assess genotyped pup disposition in a timely manner.

Maintain existing computer software-based management and record of mouse colonies.

Prepare census of all mice and submit report to PI monthly or more frequently as needed. Report census and protocol irregularities to PI, acting as first point of contact in veterinary matters. Report ongoing breeding information accurately and clearly to lab investigators. Maintain breeding of several strains of knockout mouse lines as directed by principal investigator and senior fellows.

Process YARC (Yale Animal Resources Center) animal orders and census data weekly. Check mice at least daily.

Maintain quality control standards by monitoring mouse health daily, ensuring progress of pregnant knockout mouse production, and assess breeding performance.

Coordinate with YARC to ship mouse strains worldwide, proactively tracking progress. Training for Yale procedures will be provided.

Assist and instruct lab personnel in animal procedures. Assure adherence to IACUC (Institutional Animal Care and Use Committee) protocols by lab members.

Prepare annual reports to IACUC from records and assist in protocol renewals.

Assist lab personnel in basic biochemical and molecular biology techniques and maintain inventory of molecular biology reagents.

Perform routine PCR-based Mycoplasma screening.

Cooperate with other lab personnel in the smooth functioning of the lab.

Preferred Education, Experience and Skills:

Familiarity with colony management software. Ability to manage mouse colony accurate and timely manner using appropriate software. Excellence in animal handling procedures, including determination of estrus/plugging in mated females, tail docking, toe clipping, ear tagging, weaning and genotyping-related procedures. Experience with basic molecular biology techniques, such as PCR and cloning.

Posting Disclaimer

The intent of this job description is to provide a representative summary of the essential functions that will be required of the position and should not be construed as a declaration of specific duties and responsibilities of the particular position. Employees will be assigned specific job-related duties through their hiring departments.

Affirmative Action Statement:

Yale University considers applicants for employment without regard to, and does not discriminate on the basis of, an individual's sex, race, color, religion, age, disability, status as a veteran, or national or ethnic origin; nor does Yale discriminate on the basis of sexual orientation or gender identity or expression. Title IX of the Education Amendments of 1972 protects people from sex discrimination in educational programs and activities at institutions that receive federal financial assistance. Questions regarding Title IX may be referred to the University's Title IX Coordinator, at, or to the U.S. Department of Education, Office for Civil Rights, 8th Floor, Five Post Office Square, Boston MA 02109-3921. Telephone: 617.289.0111, Fax: 617.289.0150, TDD: 800.877.8339, or Email:

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