Senior Associate Scientist, Biophysics

La Jolla, California
Sep 13, 2021
Sep 26, 2021
Jobseeker Type
Organization Type
Full Time
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.


Pfizer Oncology R&D in La Jolla, California has an open position at a senior associate scientist level (non-PhD) in the Biophysics lab within the Biochemistry and Quantitative Pharmacology group. We are an integrated and highly collaborative team of colleagues with technical expertise in biochemistry, biophysics, enzymology, and cell biology. The successful candidate will help characterize drug-protein and protein-protein interactions using label-free biophysical methods. The preferred candidate will be a highly motivated and innovative scientist with a desire to pursue challenging biomolecular targets for drug discovery. He or she will have significant knowledge in protein science and biophysical binding methods and will directly contribute to advance our cancer drug discovery portfolio at a technical and strategic level.

  • Work under supervision to characterize small molecule-protein binding interactions using label-free biophysical methods (SPR, ITC, thermal stability-based assays)
  • Use new and established plate-based methods/ workflows to routinely perform binding studies using biophysical methods
  • Analyze biophysical data and organize it for internal dissemination/publication
  • Maintain detailed and accurate records of experimental methods and results in lab notebooks
  • Identify and integrate emerging biophysical technologies to strengthen current capabilities within the group


  • Bachelor's Degree in biophysics, biochemistry, structural biology or related discipline with a minimum of 3 years of relevant laboratory experience or Master's Degree with relevant laboratory experience.
  • Basic knowledge and understanding of biomolecular binding, methods for binding measurements and their application to drug discovery.
  • Demonstration of our values of courage, excellence, equity, and joy that form the basis of our scientific collaborative culture.
  • Excellent oral and written communication skills, team orientation, and interpersonal skills to facilitate knowledge sharing and scientific discussions.

  • Industry experience.
  • Experience in biophysical methods for binding measurements (SPR, ITC, MST and thermal stability assays such as DSF).
  • Experience in proper handling of recombinant proteins as tools in biochemical or biophysical assays.
  • Experience in high-throughput screening and plate-based pharmacology.

  • The job can require standing and walking for most of the day regularly.
  • Candidate will be required to lift and transport large stacks and boxes of plates, plate stackers/hotels, and 4L bottles of liquids for use with the automated equipment regularly.
  • Candidate may need to use step stools to climb and reach items above eye level.
  • Candidate will also diagnose and repair equipment with various tools occasionally.
  • Must be able to work safely in a laboratory environment with lab coat, protective eye wear, and gloves.

  • Eligible for Employee Referral Bonus
  • Eligible for Relocation Support

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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