Associate Director / Principal Investigator/Clinical Biomarkers- Translational Science

Summary

The Associate Director / Principal Investigator will have expertise in the development, execution and oversight of biomarker plans for oncology assets and be responsible for designing and implementing translational plans for Arcus's clinical pipeline. Focus for this role will be to evaluate biological activity and patient selection strategies in early development with an emphasis on FIH/phase 1 as assets transition from discovery to development.

Responsibilities

• Collaboratively develop translational strategies which may include patient selection, pharmacodynamic, mechanism of action/resistance, rationale for combination approaches, and other clinically relevant biomarkers translational plans
• Responsible for biomarker analysis and delivery of clinical biomarker results to internal and external stakeholders working collaboratively with Biology, Clinical Science, Biometrics, Bioinformatics, Clinical Operations, CROs, and other groups
• Oversee biomarker assay identification and validation for clinical biomarkers
• Lead cross functional biomarker teams providing expertise, driving decisions as well as enabling execution
• Represent translational science function at project teams, other review forums, and to external groups as needed
• Responsible for authoring the biomarker sections of clinical protocols and regulatory documents; contribute to abstract writing and presentations at relevant conferences

Qualifications

• PhD, MD or equivalent with strong scientific background in human immunology, immunotherapy, cancer biology, and/ or translational research
• 6 + years of experience in the biotechnology or pharmaceutical industry, including 2 + years of translational research focused on oncology or immuno-oncology
• Experience in discovery and development of biomarker assays across a broad range of platform technologies (e.g., NGS, IHC, PCR, FISH, flow cytometry, ctDNA, blood-based biomarkers) preferred
• Flexible to accommodate changes in team and project needs and foster teamwork in all settings
• Familiarity with data analysis from IHC, flow cytometry, and gene expression assays
• Ability to handle multiple projects at a time and have a strong attention to detail while understanding the higher-level strategy
• Ability to work effectively in a fast-paced, team-based matrix environment as well as the ability to function independently as appropriate
• Familiarity with complex data analysis and visualization tools
• Demonstrate independent thought and creativity