Research Scientist 2

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we'll help you build a career that you can feel passionate about.

Job Summary

At Distributed Bio (a Charles River company), our mission is to define a new paradigm in revolutionary bioengineered medicines for the biotechnology industry. In monoclonal therapeutics, our integration of computational immunology, bioengineering and robotics has enabled us to create a pipeline of molecules with unprecedented biophysical properties, while also supporting all of our partners with developable antibodies against any drug target of interest.

Our ability to discover antibodies against challenging pMHC, pathogen toxin, GPCR and Ion Channel targets, as well as a novel high-throughput discovery of CAR-T, has resulted in the growth of our antibody discovery business.

We are seeking to recruit a candidate with relevant hands-on experience in mammalian protein expression, purification and analytics for the position of Research Scientist in the Protein Science department. This role will support the generation of quality recombinant proteins and panels of lead antibodies to support our client programs across all therapeutic areas.

Main responsibilities

• Expression and purification of protein molecules including antibodies, antibody fragments, Fc fusions
• Protein characterization with SDS-PAGE, HPLC-SEC MALS and Endotoxin measurements
• Data interpretation and generation of data packages with expression, purification and analytical data
• Co-ordination with project management and project leaders to deliver timely contribution to client project updates

Job Qualifications

Key requirements

• BSc or MSc in Biology, Biochemistry, or a related field with 1-2 years of relevant laboratory based experience with either protein expression and purification
• Working knowledge of protein expression in mammalian system including Expi293 cells
• Experience with AKTA System and Unicorn software is preferred
• Strong communication Skills (written and oral) and ability to work in a fast-paced environment
• Good organization skills with strong attention to details
• Working knowledge of protein expression in insect and E.coli platforms for recombinant protein expression
• Working knowledge of standard molecular biology procedures - for example vector design and engineering, PCR, cloning and mutagenesis techniques

About Discovery
Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.

At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.

Equal Employment Opportunity

Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.

If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_US@crl.com. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.

For more information, please visit www.criver.com.