Postdoctoral Associate- CAR T-cell studies

Summary

A postdoctoral position is open at The Center for Cell and Gene Therapy to conduct correlative/mechanistic studies in first-in-man Phase I clinical trials to understand mechanisms regulating leukemia and lymphoma resistance to CAR T-cell therapy and factors regulating the activity of engineered CAR T-cells in patients. Applicants are sought to design and perform correlative CAR T-cell studies on samples obtained in ongoing Phase I clinical trials of CAR T-cells as well as the GMP-manufactured CAR T-cell products. Clinical activity of CAR T-cells will be replicated in relevant PDX models.

Job Purpose

Postdoctoral Associates are trainees working in an apprenticeship mode in preparation for a career as a scientific professional.

Job Duties

• Designs and performs cell-based assays for high-throughput analyses of CAR T-cells (e.g., multimodal flow cytometry, RNA-seq).
• Analyzes multi-dimensional data in collaboration with the bioinformatics group.
• Establishes patient-derived xenograft models of leukemia and lymphoma for preclinical testing of next-generation products.
• Performs pilot experiments to test specific hypotheses in preclinical CAR-T cell development to inform the next generation of CAR T-cell therapies.
• Assists with writing reports and manuscripts and present at scientific meetings.
• Maintains a timely log of experimental notes.

Minimum Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience.

Preferred Qualifications

• Ph.D in Immunology or Cell Biology strongly desired.
• Experience with immunology, mouse models, and high-throughput single-cell assays is a plus.
• Experience in cell biology and flow cytometry is strongly preferred.
• Experience with transcriptomics / high-throughout assays is a bonus.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

8067

CA