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Research Scientist 2

Employer
Charles River Laboratories
Location
Cleveland, OH
Closing date
Sep 29, 2021

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Sector
Science
Organization Type
Corporate
For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we'll help you build a career that you can feel passionate about.

Job Summary

We are seeking a Research Scientist 2 (In Vitro Toxicology) for our Safety Assessment group site located in Cleveland, Ohio.

Serve as a scientist in the conduct of assigned nonclinical research or laboratory-based studies at all levels of complexity, to include study management, interpretation and reporting of study data, and assuring the regulatory compliance of these projects, as appropriate.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

* Function as a study director in the direction and execution of assigned studies, in compliance with Good Laboratory Practice (GLP) regulations as they apply to the conduct of nonclinical research.
* Assay development of biochemical, cellular (native and recombinant) and complex (e.g. co-cultures, primary cells, differentiated stem cells) assays in multi-well (96-well or higher density) formats with a range of readouts (e.g. absorbance, fluorescence, luminescence)
* Provide deep understanding of complex biological signaling pathways and apply this knowledge the interpretation of key results.
* Review, interpret, integrate, and present data on assigned studies with minimal assistance.
* Participate in the proposal management and bid development process, serving as a scientific contact for new business generated from established business relationships.
* Participate in and coordinate all phases of the study planning process with appropriate departments.
* Generate high-quality protocols, amendments, and reports as appropriate for assigned studies.
* Function as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
* Assist in the oversight of the laboratory and mentor technical staff in areas such as protocol interpretation, method development and refinement, study-related problem resolution, and technique validation. Provide scientific expertise in study conduct, design, and interpretation.
* Attend scientific meetings, conferences, and training courses to enhance job and professional skills. Present abstracts/posters at national meetings, when appropriate, to maintain a scientific presence and visibility in areas of individual expertise.
* Recommend and implement techniques to improve productivity, increase efficiencies, cut costs, take advantage of opportunities, and maintain state-of-the-art practices.
* Perform all other related duties as assigned.

QUALIFICATIONS:

* Education: Ph.D. in Cell Biology, Biochemistry, Toxicology or a related scientific discipline required.
* Experience: Three to 5 years related experience in a contract research organization (CRO), academic, biotechnology or pharmaceutical environment. Experience working to GLP standards and with novel alternative methods for in vitro toxicology assessment highly preferred.
* An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.
* Certification/Licensure: None.

About Safety Assessment
Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market. Each year approximately 120 investigational new drug (IND) programs are conducted in our Safety Assessment facilities.

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