Senior Scientist/Principal Investigator - Cell and Molecular Biology (DMPK)

Senior Scientist/Principal Investigator - Cell and Molecular Biology (DMPK)

Arcus Biosciences is seeking a highly motivated and team-oriented candidate for the position of Senior Scientist/Principal Investigator in the Drug Metabolism and Pharmacokinetics (DMPK) Department. The successful applicant will lead the development, validation, and application of cell based in vitro ADME assays and represent DMPK on project teams to advance our discovery and development programs.

Core responsibilities:

• Develop, optimize, and perform cell-based in vitro assays to assess CYP induction, permeability, and drug transporter interactions
• Analyze, summarize, interpret, and present assay results to project teams
• Serve as DMPK representative and subject matter expert on project teams - Identify and address critical ADME-centered issues; Provide guidance to project teams on lead optimization; Characterize, select, and advance clinical candidates with appropriate ADME properties
• Author nonclinical PK section and DMPK study reports for regulatory submissions
• Manage and mentor research associates
• Manage out-sourced DMPK studies

Qualifications:

• Ph.D. degree in molecular biology, cell biology, biochemistry, pharmaceutical sciences, or related discipline with 3+ years of industry experience
• Expertise in cell biology and molecular biology; Prior experience with cell based in vitro ADME assays is required
• Hands-on experience in LC-MS/MS quantitation is a plus
• Good understanding of principles of drug metabolism and pharmacokinetics
• Demonstrated strong analytical and problem-solving skills
• Strong work ethic, self-motivated, attention to details and ability to work collaboratively in a fast-paced, dynamic environment with effective time-management skills
• Experience managing research associates
• Excellent communication and writing skills