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Senior Scientist, Phage Display

Employer
Commonwealth Sciences, Inc.
Location
Boston, MA
Closing date
Oct 15, 2021

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Sector
Science
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Position located in Cambridge, MA.

Responsibilities of the Senior Scientist, Phage Display:
  • Work internally and externally with collaborators to design, plan and execute screening methodologies to advance novel clinical candidates in autoimmunity and oncology.
  • Responsible for automation of company's proprietary platform and training others on automation.
  • Establish, monitor, and evaluate quality assurance and quality control performance metrics to monitor sample performance, take corrective action where applicable.
  • Support and manage interactions with vendors, research associates and others to develop and maintain optimal SOPs and QC.
  • Responsible for optimization and execution of the company platform, including biochemical and molecular biology techniques (cloning of high-complexity libraries, PCR-based library preparation for Next Generation Sequencing, etc), and assay development.
  • Generate, perform, and analyze workflows pertaining to antibody profiling from bio-banked and clinical human samples.
  • Troubleshoot and innovate phage display, immunoprecipitation and ELISA techniques, and novel methods of protein fragment display.
  • Scientific creativity, critical thinking, ability to innovate, and problem solve.


Requirements of the Senior Scientist, Phage Display:
  • Ph.D. degree in Immunology, Molecular/Cellular biology or closely related field, 2+ years relevant experience in pharmaceutical or biotechnology industry.
  • Experience in high throughput pooled or DNA based genetic screens is preferred.
  • Experience in phage, yeast, insect or other protein fragment display platforms.
  • Experience establishing, programming and optimizing lab automation systems.
  • Ability to work efficiently both independently and in a team environment, demonstration of quality, proficiency, and attention to details.
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