The Global Science and Technology group in Pfizer's Comparative Medicine division is seeking an outstanding postdoctoral researcher to lead project on identifying and validating novel translationally relevant physiological endpoints in preclinical heart failure models. This is an exciting opportunity to work on complex measures of pathophysiology and disease progression in preclinical models of heart failure, and how these measurements can be used as preclinical prognostic biomarkers to aid the evaluation of novel targets against heart failure. The prospective post-doctoral fellow will be responsible in independently designing and performing pioneering experiments under supervision of the mentors. The candidate will present research work internally as well as at external scientific conferences and publish manuscripts in peer-reviewed scientific journals.
We are looking for a candidate with a research background in cardiovascular physiology, cardiac electrophysiology, rare cardiac diseases, heart failure, or cardiac metabolism. This project is ideally suited for a candidate looking to expand their interdisciplinary skills and gain exposure in drug discoveryROLE RESPONSIBILITIES
This post-doctoral fellow will be responsible for developing translational techniques, protocols, and pre-clinical models to understand physiological measures in preclinical models of heart failure. The position involves independent thinking, literature search and execution of experiments under minimal supervision.
- Develop, refine, and validate preclinical models of heart failure
- Design and execute pre-clinical experiments to identify and validate translationally relevant prognostic markers in validated models of heart failure
- Perform in vivo technique such as echocardiography, contrast enhanced ultrasound, exercise tolerance test, calorimetry , cardiovascular telemetry
- Acquisition and analysis of ECG data from preclinical models of HF
- Collaborate across the cross functional team to leverage the resources and conduct the studies efficiently.
- Present the work at various meetings and publish the work in reputed journals in the field.
- PhD in cardiovascular physiology, cardiovascular pharmacology, cardiac metabolism, or veterinary sciences.
- 0-3 years of postdoctoral training in academia or industry.
- Experience in preclinical models of heart failure.
- Strong collaborative spirit and writing skills evidenced by lead author publications in high impact peer reviewed journals.
- Experience in ultrasound based imaging, including echocardiography
- Experience in acquisition and analysis of telemetered ECG data
Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.Sunshine Act
- Primarily sitting at adesk and moving through offices.No extra-ordinary requirements.
- The position will also involve complex data or image analysis which involves advanced software and tools.
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Research and Development