Why Patients Need You
Everything we do, every day, is in line with an unwavering commitment to the quality and the delivery of safe and effective products to patients. Our science and risk-based compliant quality culture is flexible, innovative, and customer oriented. Whether you are involved in development, maintenance, compliance or analysis through research programs, your contribution will directly impact patients.What You Will Achieve
The Cancer Immunology Discovery group at Pfizer is seeking a highly motivated and creative Scientist at the BS/MS level to join the T cell activation and PDx resistance team to identify and evaluate novel therapies in the fields of Cancer Immunotherapy and Immune Checkpoint Biology. The candidate will provide scientific and technical support and work closely with other disciplines across Pfizer to drive discovery research programs into early clinical development. Specifically, the candidate will delineate mechanisms of action, develop biomarker detection methods and support the identification and development of molecules that impact T cell and myeloid cell function to enhance anti-tumor immunity. The successful candidate will use a variety of tools including, molecular, cellular, and biochemical techniques, as well as modern imaging techniques, systems immunology, bioinformatics, and preclinical in vitro and in vivo models. How You Will Achieve It
- Contribute to the discovery and development of new small and large molecule therapeutic modalities for cancer immunotherapy.
- Execute and may design mechanistic, PD, and biomarker studies for preclinical-stage therapies using in vitro and ex vivo assays, including but not limited to multi-parameter flow cytometry (including PhosphoFlow), western blotting/IP, gene expression analysis techniques, and functional assays.
- Work in a matrixed environment and collaborate with multiple disciplines to identify and pursue the most promising drug candidates.
- Participate and present in internal and external project meetings as well as at site and cross-site meetings.
- Communicate experimental findings accurately and concisely in both oral and written formats.
- Bachelor of Science degree in Immunology, Oncology, or related discipline with 6+ years' relevant post-graduate industry experience or MS degree with 5+ years'.
- Technical background in molecular immunology, including assessment of protein post-translational modifications
- Experience in standard immunologic and cell culture techniques including primary cell subset isolation and culture.
- Excellent organization skills and good verbal and written communication.
- Ability to plan, execute, and interpret experiments.
- Ability to effectively collaborate in a matrixed work environment to access diverse technical specialties
- The ability to work independently and as part of a team in a fast-paced environment.
- Strong motivation with a dedicated work ethic.
- Experience with T cell or myeloid/dendritic cell biology assays including activation, differentiation, proliferation, cytotoxic and suppression assays.
- Broad technical expertise in assessing T cell phenotype and function in vivo/ex vivo (flow cytometry, qRT-PCR, MSD, (confocal) microscopy, CRISPR/ lentiviral transduction).
- Experience investigating T cell-specific inhibitory/co-stimulatory molecules and their associated signal transduction pathways (western blot, reporter assays, phosphoFlow).
- Ability to perform complex data analysis.
- Ability to interpret and apply results in the context of Pfizer programs and published literature.
- Strong interpersonal skills and a desire to succeed in a team setting.
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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