This job has expired

Principal Scientist, Medicinal Chemistry

Groton, Connecticut
Closing date
Oct 17, 2021

View more

Science, Pharmaceutical
Jobseeker Type
You need to sign in or create an account to save a job.
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Principal Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be part of a group in Pfizer comprises experts in the major scientific disciplines involved in the discovery and preclinical development of small molecule drugs. Specifically, you will be involved in molecular design, synthesis, computational chemistry, pharmacology, chemical biology, structural biology, analytical chemistry etc.

You will play a key role in large, multi-disciplinary matrix teams from project inception through to delivery of clinical drug candidates. You will also contribute to teams of scientists looking to combine Pfizer's expertise and large-scale research investments, with external academic and biotech collaborations.

In your role, you will be recognized as a technical expert and a significant scientific contributor. With your deep knowledge of the discipline, you will help in revolutionizing our approach in the discovery and development of small molecule and synthetically-derived drugs. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will undertake mentoring activities to guide team members.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

  • Contribute at the therapeutic area level and represent the group on multidisciplinary teams.
  • Influence at the therapeutic area or discipline level and increasingly at the project team level.
  • Partner with other team leaders to shape and influence the strategy of medicinal chemistry project{s} through the enablement of innovative synthesis for the delivery of incumbent compounds.
  • Assist development and enablement of versatile and modular synthetic routes compatible with rapid analog synthesis.
  • Build internal/external recognition of the teams and Research Units (RU) through effective communication on project strategies and plans.
  • Seek to deliver project objectives in line with allocated resources under time constraints in collaboration with the Project Team and leadership.
  • Drive the appropriate selection of target compounds with speed to Proof of Concept (PoC).
  • Promote the professional and scientific development of direct reports.
  • Make effective use of both internal & external design resources available to the project team.



  • Bachelor's Degree with 12+ years of experience or PhD with 4+ years of relevant experience
  • Experience in the application of innovative methodologies for successful execution of highly challenging synthetic chemistry
  • Proven track record of creative thinking as demonstrated by publication, presentation or patent records
  • Understanding of key concepts from relevant partner disciplines including Pharmacology, ADME, Pharmaceutical Sciences and Drug Safety
  • Expert understanding of and contributor to the chemical literature
  • Comprehensive knowledge of established and modern synthetic methodologies
  • Demonstrate effective supervisory skills with strong focus on developing talents and promoting colleague engagement and productivity


  • PhD and 4+ years of relevant experience
  • Prior experience mentoring junior scientists

Additional Job Information
  • Last Date to Apply is October 15, 2021
  • Eligible for employee referral bonus
  • Relocation Support Available

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
You need to sign in or create an account to save a job.

Get job alerts

Create a job alert and receive personalised job recommendations straight to your inbox.

Create alert