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Staff Scientist - Metabolism, Cancer Cell Signaling and Mouse Modeling

City of Hope
Bradbury, CA
Closing date
Jan 20, 2022

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Science, Life Sciences, Cell and Molecular Biology, Nursing, Oncology Nursing
Organization Type
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About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

We are looking for a Staff Scientist to join Dr. Danilov's lab which is highly translational and involves work with primary samples from patients with lymphoma. Based on laboratory findings, Dr. Danilovs group originates early-phase clinical trials, allowing for verification of laboratory findings in the clinical setting. The translational project will focus on cancer cell signaling and investigate novel molecular targets in B-cell malignancies. The areas of interest in the laboratory are:

• Novel targets within the ubiquitin-proteasome pathway

• Mechanism of action and resistance to transcriptional CDKs.

This position is designed to continue research studies currently funded by the Leukemia and Lymphoma Society Translational Research Program Award and Scholar Award. This grant focuses on understanding how sumoylation regulates metabolism in B-cell neoplasia. The ideal candidate will have extensive experience in the field of metabolism and cancer cell signaling and be familiar with mouse modeling techniques. He or she should have a successful track record of publications and must have demonstrated collaborative skills, as demonstrated in multiple collaborative publications. Highly motivated candidates with expertise in molecular biology, hematopoiesis, and in vivo models who are interested in a career in oncology basic/translational research will be most competitive for this position.

The individual will have at least 3 years of post-graduate research experience in the relevant field. They are likely to have deep expertise in a singular area of focus but may also have worked as boundary spanners across multiple fields. Achieving this position requires that the researcher has demonstrated a satisfactory track record of scholarly activity including high-quality peer-reviewed publications. To maintain successful track record and show potential of growth, the individual must be actively engaged in publishing high-quality manuscripts, the development and submission of grant/funding proposals and leading projects that are aligned with the lab's focus area.

Responsibilities Include:

• Leading a collaborative research project focused on extrinsic mechanisms and drug resistance.

• Maintaining a high level of professional expertise in the field

• Supervising and providing guidance and mentorship to other researchers within the laboratory

• Designing and directing or executing experiments

• Establishing laboratory procedures and systems that enforce and maintain a high level of organization in the lab.

Basic education, experience and skills required for consideration:

• Doctoral degree in relevant field and 3-5 years of relevant post-doctoral work experience.

• 5+ years in a research position, including at least 4 years of supervisory and project management experience.

• Expertise in cancer biology, molecular/hematopoiesis, and genomics required. Experience with murine leukemia, hematopoiesis, and in FACS based methods, biochemistry, and molecular biology strongly preferred

• Proficient with computers specifically MS Office (which includes, Excel, Access, Word and PowerPoint) and statistical analysis software

• Strong publication record

• Experience handling chemical and biologically hazardous materials.

• Knowledge of policy and regulations applicable to the laboratory, including but not limited to safety, animal, and radiation.

• Technical proficiency, scientific creativity collaborative ability, and independent thinker

• Experience with drug sensitivity/synergy analyses preferred

Additional Information:

• To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
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