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Lead Bioinformatics Scientist

Employer
Medical Science & Computing , a Dovel company
Location
Westlake, MD
Closing date
Dec 1, 2021

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Sector
Science
Organization Type
Corporate
We are currently searching for a Lead Bioinformatics Scientist to provide support services to satisfy the overall operational objectives of the NCI/CCR/Genetics Branch-OMICS Facility. Primary objective is to provide services and deliverables through performance of support services. This opportunity is full-time, and it is on site in Bethesda, MD.

Duties & Responsibilities
  • Collaborate with Genetics Branch PIs, biologists, clinicians, PI team based computational staff, and OMICS facility staff to understand their experimental and technical goals and suggest statistical and bioinformatics solutions for biological and translational questions such as mechanisms of oncogenesis, drug target discovery, drug mechanism elucidation and patient stratification efforts
  • Design and implement state-of-the-art computational methods; use existing open-source algorithms and develop custom algorithms to answer key cancer genomics questions using data from short Illumina and long-read multiple technologies whole genomics sequencing, short-read- Illumina and long-read PACBio whole transcriptome sequencing, single cell RNAseq, single cell ATACseq, ChipSeq, HiC, HiChiP, spatial transcriptomics, mass spec proteomics, immunopeptidomics, and spatial proteomics including CyTOF Imaging Mass Spectrometry and microarray data sets
  • Develop and implement codes to analyze histological images, spatial transcriptomic or pro-teomic and other digital imaging data
  • Provides programming and troubleshooting support to the Federal Government in the dissemination of research data.
  • Ensuring that Github is maintained for all codes developed by incumbent
  • Performs computations on research data analysis.
  • Participate in the optimization of the data life cycle for each project including the use of local and central archival storage, and the submission of mature datasets to the appropriate public databases
  • Updating codes to current versions on a 6 monthly basis and making and documenting improvements to the current codes
  • Integrating somatic mutations, translocations, amplifications, deletions, proteomics and epigenetics data into databases for visualization
  • Incorporate newly generated omics data sets in large-scale databases to support data-mining including integration with publicly available omics databases
  • Develop and implement machine learning including artificial and convolutional neural networks and other sophisticated algorithms
  • Works with staff on scientific programming and experimental design.
  • Work with GB collaborators
  • Work with staff on scientific programming and experimental design Prepare summaries and reports; attend meetings; present results and findings to staff
  • Records observations and report results at weekly laboratory meetings.
  • Reading and presentation of current literature relevant to current ongoing efforts
  • Collect reports
  • Provides statistical support / analysis on research data.
  • Provides research / service goals in the context of the laboratory's overall mission.
  • Evaluates new types of experimental approaches to protocols based on knowledge of scientific literature, available facilities and research needs.
  • Create generalizable code bases to improve and support development of pipelines for the analysis, interpretation and visualization of next-generation sequencing data Develop interactive shareable code solution using technologies like Jupyter KnitR for collaborators and actively maintain them in a centralized version controlled repository in Github
  • Independently coordinates the training of personnel in the use of scientific software applications, statistical software applications and programmatic software applications


# SOAR
Requirements Skills
  • Experience in leading/supervision of staff
  • Experience in working with Next Generation Sequencing Data
  • Familiarity with Genomics
  • Next gen sequencing data analysis: Bulk RNA-Sequencing
  • Cloud-Based Computing
  • Strong communications skills, both oral and written
  • Excellent analytical, organizational and time management skills
  • Single Cell RNA-Sequencing
  • Microarray data analysis
  • Working in Linux/Sever/Cloud environment.
Qualifications
  • PhD in Biology, Life Sciences or a related discipline.
  • Minimum of four (4) years of experience in bioinformatics or computational biology or programming.


Due to our contractual requirements and federal orders, including an Executive Order from the White House and an emergency regulation from the Centers for Medicare & Medicaid Services (CMS), the position for which you are applying requires that you provide proof of your vaccination status. If you are unable to receive the COVID-19 vaccine for medical reasons or because of a sincerely held religious belief, you may request an exemption from the vaccination requirement which shall be reviewed after the submission of requested documentation. If an accommodation is granted, the conditions may include weekly testing and masking. All Guidehouse employees also agree to follow any additional health and safety mitigation policies that may be required in the workplace.

Company Description
We are a trusted government partner that blends deep domain expertise with advanced technologies to help our customers solve complex problems that improve, protect, and save lives. As a rapidly growing company, we combine entrepreneurial spirit, customer focus, and an outcomes-based approach to support agency missions in health IT, life sciences, public safety, and grants management.

The Dovel Family of Companies offers employees an opportunity to advance beyond a specific role or contract, we offer a path to develop an enriching career. We believe in empowering a culture of innovation, customer success, and employee growth.

What you'll get...
  • Time Off! Flexible schedules and company paid holidays allow you to take the time you need.
  • Investment in YOU! 401(K) company contributions are yours to keep with no waiting period.
  • Choices! Unique healthcare plans to choose from with options like fertility and orthodontia benefits.
  • Discovery! With our tuition assistance and training programs, we support your career advancement.
  • Tax Savings! Enroll in pre-tax Health or Dependent Care Flexible Spending, HSA with company contributions, parking, and/or transit commuter benefits.
  • Support! Working parents and busy professionals - we've got you covered with a supportive culture, confidential Employee Assistance Program and a membership to Care.com.
  • Perks! Employee discounts, peer recognition programs, company-wide wellness challenges, and fun community events.
  • A Voice! A unique culture where you can influence decisions and have your voice heard.


We are an Equal Opportunity Employer with a commitment to diversity. All individuals, regardless of personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, sexual orientation, gender identity, disability, or veteran status.

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