Senior Scientist, Protein Sciences

Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

ROLE SUMMARY

As a Senior Scientist in the Cellular, Genomic, and Protein Sciences (CGPS) department, you will be at the center of our protein expression and purification operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be responsible for construct design and purification from bacterial, insect, and mammalian cells. With your deep knowledge of the discipline, you will be recognized as a technical expert and a scientific contributor who routinely partners with and mentors junior colleagues within the department and across therapeutic areas. Your innovation and creativity in developing novel processes and new ideas will be frequently used to drive decision making impact across the portfolio and establish a world-leading Protein Sciences pipeline to serve a world-leading Drug Discovery pipeline.

ROLE RESPONSIBILITIES

• Represent Protein Sciences at the project team level, helping to guide new targets from gene to screen.
  
• Troubleshoot scientific and technical challenges. Mentor more junior scientists to do the same.
  
• Design constructs for expression in bacterial, insect, and mammalian cells to produce high quality recombinant proteins, protein complexes, and RNA.
  
• Purify and characterize recombinant proteins to enable high throughput assays, biophysical assays, and structural efforts.
  
• Prepare internally reviewed technical reports, make oral presentations to scientists and management, and publish externally.
  

BASIC QUALIFICATIONS

• PhD and Postdoc in Biochemistry, Structural Biology, or a related discipline or M.S. with 7+ years of experience including industry experience.
  
• Experience in expression construct design for high yield protein production in bacterial, insect, and mammalian cells.
  
• Demonstrated ability to purify proteins ranging from protein domains to challenging large multi-subunit and protein complexes and integral membrane proteins.
  
• Characterization of proteins by analytical and biophysical methods including aSEC, fSEC, DLS, DSF, SEC-MALS, and other methods to monitor conformation, oligomerization, and stability.
  
• Experience using Akta purification systems.
  
• Strong understanding of protein chemistry and protein analytics, including the recent scientific literature.
  
• Demonstrated ability to obtain results and drive innovative research programs independently.
  
• Strong working knowledge of the drug development process for progression of projects to identify lead compounds and/or proteins.
  
• Self-motivated, organized, and capable of working independently and in a collaborative environment.
  
• Strong oral and written communication skills.
  

NICE-TO-HAVE

• Phage, yeast, or mRNA display for generation of antibodies, single domain antibodies, or scFv
  
• Scientific programming and data analysis skills
  
• Knowledge of Rosetta or other popular modeling software
  

PHYSICAL/MENTAL REQUIREMENTS

Sitting, standing, lifting, bending, and walking. Ability to perform practical laboratory bench work and work on a computer (while standing or sitting). Ability to perform mathematical calculations and interpret data.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• Minimal, if any travel related to this position. Candidate may periodically be asked to travel to the Pfizer Cambridge, MA site to meet project team members.
  
• Candidate must comply with laboratory safety practices.
  

ADDITIONAL JOB INFORMATION

• Relocation support available
  
• Eligible for employee referral bonus
  

#LI-PFE

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development