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Senior Scientist, In Vivo (Oncology)

Cambridge, Massachusetts
Closing date
Dec 2, 2021

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Science, Pharmaceutical
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Site Name: Cambridge 300 Technology Square Posted Date: Oct 27 2021 re you energized by a challenging role in in vivo Oncology, where scientific demand is driving team growth? If so, this Sr. Scientist role would be a great opportunity to consider. We are seeking a highly motivated, enthusiastic and skilled in vivo scientist to join the in vivo pharmacology team within GSK Oncology Synthetic Lethality Research Unit located in Cambridge, MA site. The successful candidate will work together with a highly motivated team to discover and develop novel oncology drugs with a clear genetic relationship to cancer. The primary responsibility of this position will be to design, conduct, interpret, and present in vivo anti-tumor efficacy and PK/PD studies for drug candidates in both CDX and PDX xenograft and syngeneic models. The candidate must be proficient in all forms of compound administration, including IV dosing. This position will also require tissue harvest for PK/PD and potentially PD analysis using various cell/ molecular biology techniques As a Sr. Scientist, contributing to various studies and be responsible for delivering pre-clinical and clinical data analysis. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following… The successful candidate will work together with a highly motivated team to discover and develop novel oncology drugs with a clear genetic relationship to cancer. The primary responsibility of this position will be to perform in vivo anti-tumor efficacy and PK/PD studies for drug candidates in both xenograft and syngeneic models. Why you? Basic Qualifications: Minimum of a Bachelor of Science degree and 3 years of hands-on experience for working with murine tumor models. Two or more years experience with cell culture is required. Preferred Qualifications: BS (biology/pharmacology) and at least 1-3 years of experience of working with rodents. Three or more years experience with mouse handling, dosing (PO, IV, IP), blood collection, and tissue harvesting, caliper tumor measurements, and tissue sampling skills enabling the ability to independently conduct in vivo studies assessing tumor growth, efficacy and PK/PD of pharmacological agents in CDX and PDX xenograft and/or syngeneic mouse tumor models One or more years experience in adopting new methods and protocols related to in vivo and ex vivo experiments The candidate must be highly motivated with excellent communication skills and demonstrated ability to work in a team and matrix environment Strong computer skills, including proficiency with commonly used data analysis programs such as Excel and Prism strongly preferred. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. *This is a job description to aide in the job posting, but does not include all job evaluation details. Ensure appropriate use of animals in compliance with all regulatory requirements and internal standards *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
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