Site Name: Cambridge 300 Technology Square Posted Date: Oct 27 2021 re you energized by a challenging role in in vivo Oncology, where scientific demand is driving team growth? If so, this Sr. Scientist role would be a great opportunity to consider. We are seeking a highly motivated, enthusiastic and skilled in vivo scientist to join the in vivo pharmacology team within GSK Oncology Synthetic Lethality Research Unit located in Cambridge, MA site. The successful candidate will work together with a highly motivated team to discover and develop novel oncology drugs with a clear genetic relationship to cancer. The primary responsibility of this position will be to design, conduct, interpret, and present in vivo anti-tumor efficacy and PK/PD studies for drug candidates in both CDX and PDX xenograft and syngeneic models. The candidate must be proficient in all forms of compound administration, including IV dosing. This position will also require tissue harvest for PK/PD and potentially PD analysis using various cell/ molecular biology techniques As a Sr. Scientist, contributing to various studies and be responsible for delivering pre-clinical and clinical data analysis. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following… The successful candidate will work together with a highly motivated team to discover and develop novel oncology drugs with a clear genetic relationship to cancer. The primary responsibility of this position will be to perform in vivo anti-tumor efficacy and PK/PD studies for drug candidates in both xenograft and syngeneic models. Why you? Basic Qualifications: Minimum of a Bachelor of Science degree and 3 years of hands-on experience for working with murine tumor models. Two or more years experience with cell culture is required. Preferred Qualifications: BS (biology/pharmacology) and at least 1-3 years of experience of working with rodents. Three or more years experience with mouse handling, dosing (PO, IV, IP), blood collection, and tissue harvesting, caliper tumor measurements, and tissue sampling skills enabling the ability to independently conduct in vivo studies assessing tumor growth, efficacy and PK/PD of pharmacological agents in CDX and PDX xenograft and/or syngeneic mouse tumor models One or more years experience in adopting new methods and protocols related to in vivo and ex vivo experiments The candidate must be highly motivated with excellent communication skills and demonstrated ability to work in a team and matrix environment Strong computer skills, including proficiency with commonly used data analysis programs such as Excel and Prism strongly preferred. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. *This is a job description to aide in the job posting, but does not include all job evaluation details. 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