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Senior Research Scientist, Assay Development & Scientific Outreach

Broad Institute
Somerville, MA
Closing date
Nov 29, 2021

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Job Description

Embedded within the Broad Institute, the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional "drug hunters". Our mission is to translate cutting edge biological insights originating from the Broad community into impactful drug discovery projects. In executing this mission we bring together faculty from MIT, Harvard, and the Harvard teaching hospitals together with industry partners in venture capital, biotechnology, and pharmaceutical companies. We combine our deep expertise in drug discovery with the knowledge and unique capabilities of the Broad Institute to address a wide range of disease areas including oncology, cardiovascular disease, psychiatric disease, infectious disease, and rare diseases. Our goal is to embrace Broad's culture of creativity and open sharing to de-risk therapeutic hypotheses, validate new targets, and advance new therapies that will improve human health globally.

As the Senior Research Scientist, Scientific Outreach, CDoT, you will be the scientific lead for CDoT's screening outreach efforts; the primary point of collaboration with scientists outside of CDoT on the design, execution, and follow-up of medium- to high-throughput screening campaigns. Working in concert with CDoT cellular pharmacology, biochemistry, automation, and compound management groups, the successful candidate will have the ability to build strong partnerships with Broad-affiliated faculty labs and external academic collaborators to influence and drive hit-finding approaches.

What responsibilities will you get when working with us?
  • Lead all stages of collaborative screening efforts (assay development and validation, pilot design and execution, assay troubleshooting, primary and secondary screening, data analysis, summary preparation and presentation, follow-up recommendations), guiding partners to the optimal screening format, library, and platform. Collaborations range from multi-institution projects to single plate cell painting requests
  • Proactively build relationships across the institute to promote CDoT capabilities and expertise
  • Balancing the needs of multiple stakeholders, in partnership with CDoT project management, design, communicate, and execute project plans incorporating screening objectives, timelines, budgets, and resource requirements
  • Present project results internally and externally including regular updates to CDoT leadership on the breadth of outreach screening activities
  • Engage with potential collaborators through outreach activities including program meetings and via portals including the Broad Drug Repurposing Hub
  • Develop biochemical and cellular assays (e,g, luminescence/fluorescence-based readouts, flow cytometry, high-content imaging) using recombinant protein or primary or cultured cells
  • Mentor junior CDoT staff including direct reporting responsibilities
  • Maintain cell lines and organize cell banks for use in cellular assays
  • With CDoT automation, compound management, and informatics, develop processes that optimize the collaborative and scientific experience of our screening partners

What will you need to be successful at this role?
  • 5+ years related work experience, preferably in a biopharmaceutical company or an academic core facility, with strong analytical skills
  • Ph.D. in molecular or cell biology or similar field
  • Strong interpersonal, influencing, and collaboration skills with the ability to work in a multi-disciplinary, team-oriented, matrix environment
  • Strong laboratory management skills to schedule, prepare, maintain, and run screening campaigns across multiple instrumentation platforms and workflows
  • The ability and willingness to think creatively about the development and adoption of emerging cell biology technologies (e.g. 3-D, organoid cell culture, stem cells, organs on chips, etc.)
  • Previous experience with the drug discovery process from hit identification through early preclinical discovery preferred

All Broad employees, regardless of work location, must be fully vaccinated for COVID-19 by Tuesday, October 12, 2021. Requests for exemption for medical or sincerely held religious beliefs will be considered.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.
Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled


All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

EEO is The Law - click here for more information

Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled
Check out this video for a look into our community!Job InfoType: Full timeLocation: Cambridge, MA
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