Sr. Research Associate

Xsphera Biosciences Inc
Boston, MA
Closing date
Dec 6, 2021

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Science, Pharmaceutical, Clinical Research Associate
Organization Type
Title: Sr./Research Associate

We are looking for an energetic Sr./Research Associate to work on an ambitious project to optimize the tumor microenvironment of a human-derived 3D ex vivo model for evaluation of anticancer therapeutics. This position provides an excellent opportunity to work at the leading edge of immune-oncology and functional precision medicine.

Xsphera Biosciences is an exciting Boston-based biotechnology startup dedicated to delivering functional, precision immuno-oncology solutions for patients, providers and biopharma companies. The company is leveraging a breakthrough technology invented at the Dana-Farber Cancer Institute and licensed exclusively to Xsphera. The technology captures the patient's own tumor microenvironment on microfluidic chips as 3D cultures for the efficient testing of immune-oncology therapeutics. The company will deliver its ex vivo profiling of the tumor microenvironment as a functional assay for patient selection in clinical trials and as a precision medicine diagnostic to oncologists to help determine the most appropriate I-O therapy for each patient.


- Process tumor biopsy specimens for spheroid formation and cell culture

- Design and innovate ex-vivo conditions to preserve and maintain the tumor-immune microenvironment

- Set-up and maintain 2D and 3D cell cultures of tumor microenvironment in microfluidic chips

- Develop new 3D immune model systems

- Test experimental drugs in the 3D models, analyze drug actions and mechanisms of action on tumor viability - Process cultures for image analysis and molecular analysis

- Graphing results and statistical analysis

- Data collection, evaluation, documentation in laboratory notebook, data presentation

- Ordering, stocking and maintaining the inventory of laboratory supplies


· 1-3 years of laboratory experience in an academic or industrial setting

· Hands-on cell culture research experience

· Understanding of fundamental laboratory skills, study design, and record keeping

· Isolating DNA, mRNA, qRT-PCR or nanostring experience a plus

· Scientific curiosity and has a working knowledge of the research laboratory environment and is familiar with all basic laboratory equipment / instruments.

· Excellent communication, record keeping and organizational skills.


· MS in Cell biology/biotechnology/cancer preferred. BA/BS degree in cell/molecular biology, pharmacology or related discipline

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