Research Associate II - Human Immunology - Sign on bonus $2,000
- Employer
- University of Massachusetts Medical School
- Location
- Worcester County, MA
- Closing date
- Dec 25, 2021
View more
- Sector
- Science, Doctors, Allergy/Immunology, Pharmaceutical, Clinical Research Associate
- Organization Type
- Corporate
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Overview:
GENERAL SUMMARY OF POSITION:
The Pathology Department at the University of Massachusetts Medical School specifically focuses on immunology and immunopathology research, with the purpose of uncovering cellular mechanisms that drive disease. The NIH-funded laboratory team, led by Dr. Kiera Clayton, is currently looking to fill the position of Research Technician I or II, entry level immunologist positions. Research interests include the characterization of human NK cell, CD8+ T cell, and Chimeric Antigen Receptor (CAR) T cell responses to HIV-infected macrophages and identifying pathways involved in perforin/granzyme resistance with the goal of designing therapies to eliminate HIV-infected macrophages (). Many of these projects involve collaborations with established labs at various universities and hospitals, including Harvard University, Massachusetts General Hospital, Brigham and Women's Hospital, MIT, the Ragon Institute, Boston University, Weill Cornell Medicine, University of Toronto, and University of Miami Miller School of Medicine. Additional networks with startup and mid-level biotech companies are also established. The ideal candidate for this position would have a background in immunology, virology, and biochemistry, an interest in a career in medical sciences, and experience working in a previous laboratory setting. Training provided would prepare the candidate for graduate school, medical school, or a Research Associate position in industry. Experimental day-to-day work will include working with human samples, making HIV stocks, performing live infections, flow cytometry, molecular cloning, and microscopy. A minimum time commitment of two years is preferred.
These positions are an excellent opportunity for those applicants who have an overall interest in medical sciences and future interest in attending a graduate/medical school.
Under the direction of the Principal Investigator or Designee, the Research Associate performs a variety of complex research experiments.
Responsibilities:
MAJOR RESPONSIBILITIES:
Perform complex laboratory experiments
Conduct in-depth analysis of research experiments
Interpret data, form conclusions, and decide on and plan the next experiments to be done with a high degree of independence
Write standard operating procedures, schedule work, analyze data, maintain accurate records, and write reports
Compile and analyze data. Perform computations using image analysis software, spreadsheets, graphing, and curve fitting software
May modify protocols and be responsible for a single, independent research project
May assist with budget and/or operational aspects of grant and contract proposals
Assist in writing the text of scientific publications and grants. Review literature
Train new laboratory personnel, students, and collaborators
Comply with all safety and infection control standards
Perform other duties as required.
Qualifications:
REQUIRED QUALIFICATIONS:
Bachelor's degree in the Biological Sciences, or equivalent experience
5 years of relevant research experience.
Knowledge of Microsoft Office products
Strong ability to analyze complex visual data in a quantitative and objective manner
Judgment and action skills required to solve commonly encountered problems
PREFERRED SKILLS -
Analytical skills and the ability to resolve technical problems
Working knowledge of data management programs (FlowJo, Excel, Prism, IDEAS, SnapGene)
Flow cytometry - sample preparation, compensation, and data acquisition
Imaging Flow Cytometry, including with HIV-infected cells
SUPERVISION RECEIVED:
Under the direction of the Principal Investigator, or designee
SUPERVISION EXERCISED:
May functionally supervise aides, technicians, and associates
ENVIRONMENTAL WORKING CONDITIONS:
Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens.
Additional Information:
Perferred Skill Set and Experience:
Ability to work independently and as a team member
Good communication skills
Computer literacy
Working knowledge of clinical research protocols
Ability to perform multiple tasks independently
Analytical skills and the ability to resolve technical problems
Ability to interpret acceptability of data results
Working knowledge of data management programs (FlowJo, Excel, Prism, IDEAS, SnapGene)
Introductory level bioinformatics training (Python)
Processing of human samples, including biohazardous samples from HIV-infected individuals
Flow cytometry - sample preparation, compensation, and data acquisition
Production of high-titer HIV virus
Primary cell infection assays, with HIV virus
Co-culture assays using primary cells and viruses including HIV
Imaging Flow Cytometry, including with HIV-infected cells
Molecular cloning
CRSIPR editing of human macrophages
Western blotting
Executing protocols of routine and non-routine experiments
Perform basic design and modification of protocols
Maintaining an electronic laboratory notebook
Calculate, transcribe and analyze data
Weekly presentations of data at laboratory meetings
Independent literature searches
Assisting with organizing materials for conference presentations, grant applications and primary research publications
Maintaining and ordering supplies
Department Oveview:
The Department of Pathology at the University of Massachusetts Medical School
located in Worcester, Massachusetts, invites applications for Research positions at the
Research Technician or Research Associate level. We are seeking individuals with a BA/BS in a Biological/Life Sciences. The ideal candidate would have a background in Immunology, Virology, Molecular Biology and/ or Biochemistry; experience working in a laboratory and with techniques in these areas is preferred. We are looking for individuals with scientific curiosity, a strong work ethic and an interest in the immunological basis of health and disease. Specific research areas currently include, but are not limited to, development of immune cells and gene regulation; innate immunity, immunity to pathogens including HIV; and skin/mucosal immunology. These positions are an excellent opportunity for those applicants who have an overall interest in medical sciences and future interest in attending a graduate/medical school.
GENERAL SUMMARY OF POSITION:
The Pathology Department at the University of Massachusetts Medical School specifically focuses on immunology and immunopathology research, with the purpose of uncovering cellular mechanisms that drive disease. The NIH-funded laboratory team, led by Dr. Kiera Clayton, is currently looking to fill the position of Research Technician I or II, entry level immunologist positions. Research interests include the characterization of human NK cell, CD8+ T cell, and Chimeric Antigen Receptor (CAR) T cell responses to HIV-infected macrophages and identifying pathways involved in perforin/granzyme resistance with the goal of designing therapies to eliminate HIV-infected macrophages (). Many of these projects involve collaborations with established labs at various universities and hospitals, including Harvard University, Massachusetts General Hospital, Brigham and Women's Hospital, MIT, the Ragon Institute, Boston University, Weill Cornell Medicine, University of Toronto, and University of Miami Miller School of Medicine. Additional networks with startup and mid-level biotech companies are also established. The ideal candidate for this position would have a background in immunology, virology, and biochemistry, an interest in a career in medical sciences, and experience working in a previous laboratory setting. Training provided would prepare the candidate for graduate school, medical school, or a Research Associate position in industry. Experimental day-to-day work will include working with human samples, making HIV stocks, performing live infections, flow cytometry, molecular cloning, and microscopy. A minimum time commitment of two years is preferred.
These positions are an excellent opportunity for those applicants who have an overall interest in medical sciences and future interest in attending a graduate/medical school.
Under the direction of the Principal Investigator or Designee, the Research Associate performs a variety of complex research experiments.
Responsibilities:
MAJOR RESPONSIBILITIES:
Perform complex laboratory experiments
Conduct in-depth analysis of research experiments
Interpret data, form conclusions, and decide on and plan the next experiments to be done with a high degree of independence
Write standard operating procedures, schedule work, analyze data, maintain accurate records, and write reports
Compile and analyze data. Perform computations using image analysis software, spreadsheets, graphing, and curve fitting software
May modify protocols and be responsible for a single, independent research project
May assist with budget and/or operational aspects of grant and contract proposals
Assist in writing the text of scientific publications and grants. Review literature
Train new laboratory personnel, students, and collaborators
Comply with all safety and infection control standards
Perform other duties as required.
Qualifications:
REQUIRED QUALIFICATIONS:
Bachelor's degree in the Biological Sciences, or equivalent experience
5 years of relevant research experience.
Knowledge of Microsoft Office products
Strong ability to analyze complex visual data in a quantitative and objective manner
Judgment and action skills required to solve commonly encountered problems
PREFERRED SKILLS -
Analytical skills and the ability to resolve technical problems
Working knowledge of data management programs (FlowJo, Excel, Prism, IDEAS, SnapGene)
Flow cytometry - sample preparation, compensation, and data acquisition
Imaging Flow Cytometry, including with HIV-infected cells
SUPERVISION RECEIVED:
Under the direction of the Principal Investigator, or designee
SUPERVISION EXERCISED:
May functionally supervise aides, technicians, and associates
ENVIRONMENTAL WORKING CONDITIONS:
Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens.
Additional Information:
Perferred Skill Set and Experience:
Ability to work independently and as a team member
Good communication skills
Computer literacy
Working knowledge of clinical research protocols
Ability to perform multiple tasks independently
Analytical skills and the ability to resolve technical problems
Ability to interpret acceptability of data results
Working knowledge of data management programs (FlowJo, Excel, Prism, IDEAS, SnapGene)
Introductory level bioinformatics training (Python)
Processing of human samples, including biohazardous samples from HIV-infected individuals
Flow cytometry - sample preparation, compensation, and data acquisition
Production of high-titer HIV virus
Primary cell infection assays, with HIV virus
Co-culture assays using primary cells and viruses including HIV
Imaging Flow Cytometry, including with HIV-infected cells
Molecular cloning
CRSIPR editing of human macrophages
Western blotting
Executing protocols of routine and non-routine experiments
Perform basic design and modification of protocols
Maintaining an electronic laboratory notebook
Calculate, transcribe and analyze data
Weekly presentations of data at laboratory meetings
Independent literature searches
Assisting with organizing materials for conference presentations, grant applications and primary research publications
Maintaining and ordering supplies
Department Oveview:
The Department of Pathology at the University of Massachusetts Medical School
located in Worcester, Massachusetts, invites applications for Research positions at the
Research Technician or Research Associate level. We are seeking individuals with a BA/BS in a Biological/Life Sciences. The ideal candidate would have a background in Immunology, Virology, Molecular Biology and/ or Biochemistry; experience working in a laboratory and with techniques in these areas is preferred. We are looking for individuals with scientific curiosity, a strong work ethic and an interest in the immunological basis of health and disease. Specific research areas currently include, but are not limited to, development of immune cells and gene regulation; innate immunity, immunity to pathogens including HIV; and skin/mucosal immunology. These positions are an excellent opportunity for those applicants who have an overall interest in medical sciences and future interest in attending a graduate/medical school.
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