Vice President, Head of Preclinical Development

American College of Clinical Pharmacology

• Vice President, Head of Preclinical Development

Vice President, Head of Preclinical Development
Magenta Therapeutics is a clinical-stage biotechnology company developing therapeutics to reset the immune system to cure more patients with devastating and life-threatening diseases. This immune reset approach can be applied through stem cell transplant to multiple diseases, including autoimmune diseases, such as multiple sclerosis and systemic sclerosis; blood cancers, such as acute myeloid leukemia; and genetic diseases, such as sickle cell disease.

Magenta's comprehensive approach to precision immune system reset will transform many aspects of the transplant process, aiming to make it safer and more effective. Our culture is fueled by a driven, passionate group of people committed to making a difference, seizing opportunities for maximum impact, and pursuing progress for the patients we seek to serve.

We are seeking a talented scientific strategist and experienced people leader to lead Pre-clinical Development. Reporting to the CSO, the Vice President of Preclinical Development will be an integral member of the Research Leadership Team and will be responsible for pre-clinical pharmacology and Toxicology for all Magenta programs focused on developing novel therapeutics to improve stem cell transplantation. You will have the opportunity to set strategy and play a key role in contributing to Magenta's corporate research goals. The VP Preclinical Development will be responsible for progressing programs from discovery through full clinical development.

You are perfect for this role if you are engaged by and want to be responsible for:

• Leading in vivo pharmacology efforts and a highly efficient team. Facilitate collaboration with project and functional teams
• Toxicology studies (non-GLP and GLP) across all phases of clinical development
• Provide strategic and scientific leadership as part of cross-functional research teams
• Serve as an internal subject matter expert for the design, execution, and interpretation of pharmacology and toxicology experiments
• Development of pharmacology data-packages and both non-GLP and GLP toxicology studies to support project advancement through clinical development
• Communicating scientific data internally and externally, authoring/reviewing study reports and regulatory documentation, contributing to high impact scientific manuscripts, identifying & managing external research collaborations, and engaging with scientific advisors and consultants
• Manage, guide, and mentor the in vivo pharmacology team, and oversee vivarium operations
• Plan, resource and prioritize in-house and outsourced pharmacology activities
• Provide support and guidance for in vivo work with several exciting external academic/industry collaborators and with CROs

We would be thrilled if you brought the following with you:

• MS/PhD with 15+ years of industry experience in drug discovery and development setting
• Demonstrated ability to advance programs from discovery through lead optimization and IND with small molecule, antibody or antibody drug conjugate molecules
• Deep understanding of in vivo pharmacology and strong track record of driving research stage programs into the clinic
• Board certification in Toxicology (DABT)
• Experienced in delivering high quality non-clinical data packages for drug candidate selection of molecules for hematologic malignancies
• Ability to work productively with, and influence, diverse project leads and work with cross functional project teams
• Previous experience in leading a team of people managers is preferred
• Ability to think strategically and execute tactically
• Excellent verbal and written communication skills, strong presentation skills, and demonstrated ability to manage by influence and problem solve in a highly matrixed organization
• Prior success with research in a hands-on, highly collaborative growth environment the ability to work effectively both independently and as part of multi-disciplinary team in a fast-paced environment
• Experience working in cultures where courage, commitment and excellence are the backbone of the leadership profile

Successful leaders and contributors within Magenta are:

• Driven. You will be focused on the achievement of Magenta's mission and major corporate goals.
• Results-focused. Demonstrated record of exceeding stretch goals, and willing to bring creative problem-solving skills to challenges along the way
• Intuitive. You will enjoy learning and being involved in the content of our whole business, thriving on a very fast-paced and growing business
• Collaborative. You will have demonstrated the ability to achieve objectives across complex projects and organizational structures
• Process-oriented, yet flexible. You will appreciate and be able to create and drive process, while also recognizing when flexibility is needed.
• Transparent and Articulate. You will have the ability to communicate clearly and concisely with all stakeholders
• Independent. You will be able to self-organize and operate effectively without significant day-to-day oversight, while staying tightly connected to key leaders and teams across the company
• A role model for the company's cultural pillars; Courage, Commitment & Excellence

At Magenta, we celebrate our differences. We value the power of a diverse array of folks who bring all of themselves to their work. We embrace cultural, cognitive, social, and professional diversity because we know the only way we're going to make new cures possible is by working together.

Job Information

• Job ID: 58505595
• Location:
  Cambridge, Massachusetts, United States
• Position Title: Vice President, Head of Preclinical Development

Headquartered in Cambridge, Mass., Magenta Therapeutics (Nasdaq:MGTA) is a clinical-stage biotechnology company developing therapeutics to reset the immune system in order to cure more patients with devastating and life-threatening diseases. This immune reset approach can be applied through stem cell transplant to multiple diseases, including autoimmune diseases, such as multiple sclerosis and systemic sclerosis; blood cancers, such as acute myeloid leukemia; and genetic diseases, such as sickle cell disease. Magenta's compr...

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