Associate Principal Scientist, Pharmacology

American College of Clinical Pharmacology

• Associate Principal Scientist, Pharmacology

M Associate Principal Scientist, Pharmacology

Description
Job Description

If this position will be based in the US or Puerto Rico (not applicable to positions based outside of US or Puerto Rico): Subject to applicable law, all prospective hires will be required to demonstrate that they have been fully vaccinated for COVID-19 or intend to be vaccinated for COVID-19 by November 1, 2021, or qualify for a medical or religious accommodation to this vaccination requirement. Hired candidates who are not vaccinated by November 1, 2021, and who have not been approved for a legally-required medical or religious accommodation will be subject to disciplinary action up to and including termination of employment, subject to applicable law

This is an exciting career opportunity in the Biochemistry and Biophysics Group within the Department of Quantitative Biosciences at our Research & Development Division - Boston.

Responsibilities

• Assume a leading role in devising strategy and in the development of biochemical and biophysical assay funnel to support target validation, hit-to-lead and lead optimization programs
• Represent biochemistry/biophysics within a cross functional core team to support discovery programs
• Collaborate within the pharmacology department and across functional areas to enable generation of protein/cell reagents and implementation of emerging technology platforms
• Excel in a collaborative, multifaceted, fast-paced working environment
• Perform hands-on experiments and minimal scientific/managerial supervision of junior scientist(s)

Education Requirement

• PhD degree in biochemistry, biophysics or a related discipline with a minimum of five years industry experience, preferablywith direct involvement and ability in assay development and compound profiling within a drug discovery environment or
• M.S and B.S/B.A degrees with eight to twelve years of industry experience, respectively

Experience and Skills

Required

• Proven ability to independently design, develop and implement biochemical and biophysical screening assays using an array of detection modalities
• Conducting biochemical and biophysical studies to elucidate the modes of ligand interaction and mechanisms of action on target proteins
• Peer-reviewed original research papers in one or more of the following areas: protein structure and conformation, protein-protein/protein-ligand interaction, antibody-antigen interaction, receptor pharmacology, enzyme reaction mechanisms and/or mechanism of enzyme inhibition
• Principled and strong analytical, organizational and communication skills and a proven ability to work in a team or collaboration-based environment

Preferred

• Effective in leading the integration of biochemical/biophysical assay platforms into program ROPs to drive med chem
• Direct experience conducting steady-state kinetic experiments to study enzymes and inhibitors
• Direct experience in recombinant protein expression using bacteria, insect (baculovirus) and/or mammalian cell-based systems and purification using automated chromatographic separation systems
• Use of automated liquid handlers such as Echo, Bravo, Biomek, or Hamilton
• Data analysis/visualization software such as TIBCO Spotfire and PRISM
• TR-FRET, FP, LC-MS, radiochemical, surface plasmon resonance (BIAcore), fluorescence-based thermal shift (TdF), and/or isothermal titration calorimetry (ITC)
• Mammalian cell culture techniques including transfection, IP, and proteomic analysis
• Investigating intracellular ligand target interactions

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are ...

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for ...

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Residents of Colorado

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US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

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Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic/International

VISA Sponsorship:
Yes

Travel Requirements:
10%

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:
1

Requisition ID:R140566

Job Information

• Job ID: 59637547
• Position Title: Associate Principal Scientist, Pharmacology
• Company Name: Merck & Co., Inc.
• Job Function: Other
• Job Type: Full-Time

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