Research Associate II, Upstream Process Development

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we'll help you build a career that you can feel passionate about.

IMPORTANT: In order to be considered for this position, a resume/CV must be uploaded and submitted during the application process. Please make sure work history and education are added correctly.

Job Summary

The Research Associate II, with minimal supervision, will be responsible for execution of
experiments to optimize conditions in upstream process to develop robust, scalable, and
reproducible processes for cell seed train expansion and viral vector production. He/she will also
work on sourcing reagents, equipment, and materials for specific projects, performing in-process
assay.

Duties and Responsibilities:
• Conducts experiments according to planned schedule and SOPs to culture different types
of cells for cell banking or viral vector production.
• Performs experiments follow SOPs for optimization of parameters for cell growth and
viral vector production in upstream processes.
• To maintain the lab equipment and material inventory for specific projects. Write SOPs
for equipment needed.
• Perform in-process assays follow SOPs including, but not limited to, quantitative PCR,
immunoassays and DNA purification, restriction enzyme digestion and gel
electrophoresis etc.
• To record, analyze and summarize experimental data accurately following GLP and GMP
guidelines.
• Asist supervisor in writing process development report and other related documents.
• Other tasks as needed such as buffer preparation, general laboratory maintenance and
assisting upstream GMP manufacturing.

Job Qualifications
• B.S. in Chemical & Biomolecular Engineering, Cell Biology, Biochemistry,
Biotechnology, or related field with 2-4 years of R&D experience or Master degree with
0-2 years of experience.
• Hands-on experience in adherent and/or suspension cell culture including mammalian or
insect cell culture in flask and preferable with bioreactors.
• Proven ability to work independently with minimal supervision and managing time to
work on multiple projects simultaneously.
• Excellent teamwork, collaboration, interpersonal, and communication skills (both verbal
and written).
• Computer skills including Microsoft Office (Outlook and Excel).
• Ability to learn critical thinking and troubleshooting skills.
• Well-organized and good documentation skills.

Working Conditions:
• Must be able to lift up to 40lbs,
• Must be able to work in laboratory settings and adhere to all safety precautions
• Must be able to travel between Rockville sites.
• Standing, sitting, pushing, pulling, reaching and bending

IMPORTANT: A resume is required to be considered for this position. If you have not uploaded your resume in your candidate profile, please return to upload field and attach your resume/CV.

Vaccine Mandate
Charles River is a U.S. Federal Contractor. As a result, we must follow the Presidential Executive Order to mandate vaccinations, and ensure our employees are fully vaccinated against COVID-19 by December 8, 2021. Our main priority is the wellbeing, health, and safety of our people. We will be requiring proof of vaccination from all employees.

Anyone with requests for disability-related and/or religious exemptions should contact Talent Acquisition (crrecruitment_US@crl.com) so that information can be provided about the accommodation process at Charles River.

About Biologics Testing Solutions
With more than 50 years of experience and proven regulatory expertise, the Charles River Biologics group can address challenging projects for biotechnology and pharmaceutical companies worldwide. Offering a variety of services such as contamination and impurity testing, protein characterization, bioassays, viral clearance studies and stability and lot release programs, we support clients throughout the biologic development cycle, from the establishment and characterization of cell banks through preclinical and clinical studies to marketed products. Whether clients need stand-alone services, a unique package of testing, or insourced support, our Biologics group can create a custom solution to suit their needs. Each year more than 20,000 biologic testing reports are sent each and over 200 licenses products are supported by our biologics testing solutions team.

About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 18,000 employees within 100 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world.

At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of >80% of the drugs approved by the FDA for the past 3 years.

Equal Employment Opportunity
Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.

If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_US@crl.com. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.

For more information, please visit www.criver.com.