Senior Scientist/Principal Scientist, Pharmacology

American College of Clinical Pharmacology
Blueprint Medicines is a global precision therapy company that invents life-changing therapies for people with cancer and hematologic disorders. Applying an approach that is both precise and agile, we create medicines that selectively target genetic drivers, with the goal of staying one step ahead across stages of disease. Since 2011, we have leveraged our research platform, including expertise in molecular targeting and world-class drug design capabilities, to rapidly and reproducibly translate science into a broad pipeline of precision therapies. Today, we are delivering approved medicines directly to patients in the United States and Europe, and we are globally advancing multiple programs for genomically defined cancers, systemic mastocytosis, and cancer immunotherapy.

What will you do?

Blueprint is searching for its next Pharmacology Team lead supporting the discovery and development efforts to demonstrate proof of concept in our Oncology programs eventually leading to development candidate selection. The successful applicant will be an outstanding scientist capable of directing research efforts in-house, outsourced, and supporting collaborations with KOLs in specific areas of interest to the company.

What will be your responsibilities?

• Design and interpret in vivo pharmacology studies to evaluate the activities of small molecule drug candidates, investigate their mechanisms of action, and explore novel therapeutic hypotheses
• Work seamlessly with the teams and vivarium manager to plan, resource, and prioritize in-house and outsourced pharmacology activities
• Manage and execute in vivo pharmacology research in-house in a matrixed environment, as well as support studies being performed through an extensive network of CROs
• Identify and validate pharmacodynamic biomarkers to support preclinical and clinical development
• Think strategically about drug development and drive innovative solutions to key challenges across the organization

What basic qualifications do we require?

• A strong background in oncology is required with hands-on experience with performing oncology xenograft studies including efficacy and PK/PD
• Extensive background in determining PK/PD to activity relationships in vivo in diseased and surrogate tissues
• An energetic self-starter who is adept at multi-tasking, has a track record of productivity and is capable of working both independently and as part of multiple collaborative teams
• Possess a strong attention to detail and have exceptional interpersonal, organizational, and communication skills
• Demonstrated ability to successfully influence internal and external cross-functional teams by promoting creative problem solving, clear decision-making, and accountability

What additional qualifications are we seeking?

• Solid understanding of tumor immunology and rare disease.
• Ability to work effectively with project leads and project teams that have diverse personalities and styles.
• Ability to work effectively with all collaborators in the drug discovery process: chemistry, DMPK, toxicology, bioinformatics, biology, clinical pharmacology, and translational medicine.
• Commitment to Blueprint Medicines' Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism

As a biotechnology organization, it is our responsibility to do everything we can to safeguard the health and safety of our workforce, our communities, and the patients we serve. That is why we require all employees to be fully vaccinated against COVID-19, unless we approve an exemption through a reasonable accommodation for certified health reasons or sincerely held religious beliefs. Accommodation requests for either of these reasons should be made to TotalRewards@blueprintmedicines.com.

Equity, Diversity, Inclusion and Affirmative Action

At Blueprint Medicines, we foster a culture of equity, diversity and inclusion. A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law. We are also an E-Verify Employer. We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability who requires an accommodation with the hiring process or to perform any essential functions of the position for which you are applying, please reach out to TotalRewards@blueprintmedicines.com.

We don't think in small steps. We think in giant leaps.

We are driven by the pursuit of new ideas, new innovations, and new ways of thinking.

We know that what each and every one of us matters and that our success depends on our ability to work together in a diverse community. We believe we are at our best as a company when our employees are thriving and we foster a culture that provides opportunities to grow and develop professionally, while also having fun.

Job Information

• Job ID: 59625609
• Location:
  Cambridge, Massachusetts, United States

Please refer to the company's website or job descriptions to learn more about them.

Director/Senior Director, Clinical Pharmacology

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