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Translational Medicine Scientist

Shattuck Labs, Inc.
Durham, NC
Closing date
Jan 17, 2022

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Science, Pharmaceutical, Physicians/Nurses
Organization Type
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About Shattuck Labs Shattuck Labs, Inc. (NASDAQ: STTK) is a clinical-stage biotechnology company pioneering the development of bi-functional fusion proteins as a new class of biologic medicine for the treatment of patients with cancer and autoimmune disease, with three ongoing Phase 1 clinical trials. Compounds derived from Shattuck's proprietary Agonist Redirected Checkpoint, ARC®, platform simultaneously inhibit checkpoint molecules and activate costimulatory molecules within a single therapeutic. The company's SL-172154 (SIRPα-Fc-CD40L) program, which is designed to block the CD47/SIRPα checkpoint interaction and simultaneously agonize the CD40 pathway, is being evaluated in two Phase 1 trials. A second product candidate, SL-279252 (PD1-Fc-OX40L), is being evaluated in a Phase 1 trial in solid tumors or lymphomas. Additionally, the company is advancing a proprietary Gamma Delta T Cell Engager, GADLEN™, platform, which is designed to bridge gamma delta T cells to tumor antigens for the treatment of patients with cancer. Shattuck has offices in both Austin, Texas and Durham, North Carolina. For more information, please visit: Position Summary Shattuck Labs is seeking a highly motivated Translational Medicine scientist with expertise in translational aspects of clinical development in the fields of immuno-oncology and immunology. The individual will be responsible for the oversight of biomarker programs of early-stage clinical studies translating scientific discoveries into clinical strategies, enabling pharmacodynamic biomarker assessment, and providing insight into combination strategies. The successful candidate will contribute to the pipeline from portfolio entry to Proof-of-Concept and is expected to work as member of a cross functional team, participate and contribute to team meetings, present at internal and external meetings. Principal Duties and Responsibilities: * In collaboration with individuals from Research, Clinical Development and Clinical Operations, the individual will evaluate technologies and platforms to aid in defining and implementing the biomarker strategy in support of clinical development. * Responsible for oversight of blood-based assay development and optimization, such as immunophenotyping, Tetramer, ICS, TCR and other assays. * Responsible for oversight of immunology and genomics assay development. * Support the review of the biomarker sections of the clinical protocol, study/lab manuals and preparation of data packages for publication/presentation and/or submission to regulatory agencies. Review technical documents including SOPs, development/qualification of protocols and drafting of study reports. * Prepare and/or direct the preparation and review of protocols, clinical study reports and translational medicine sections of translational plans, INDs, abstracts, manuscripts, and technical reports. * Oversee delivery of clinical PD data and PD data analysis and identify and collaborate with academic translational sites to optimize the translational strategy and plans. * Support the clinical research team in analysis of biomarker data and contribute to internal and external scientific discussions and engagement with KOLs in the field. * Identify and establish agreements with contract research organizations (CRO) and participate in execution of assays at these centers. Responsible for presentation of results and updates of projects at department, project, corporate and scientific meetings. Required Qualifications and Skills * PhD degree in a relevant scientific field (e.g, immunology) with a minimum of 6 years of industry and/or translational research experience required. * Training in Immunology strongly preferred to champion the translation of novel scientific discoveries into clinical development. * Scientific expertise in cancer biology, cancer genomics, immuno-genomics is preferred. * Experience with high dimensional data analysis is a plus. * Experience in development and validation of clinical biomarker assays is a plus. * Ability to demonstrate effectiveness and growth in a fast-paced and dynamic environment Note to External Recruiters: Our Human Resources department manages all open positions and candidate recruitment. We kindly ask that recruiters not contact employees or hiring managers directly to present candidates or solicit business. Please note that we will consider failure to comply with this request when determining whether to enter into a professional relationship with a recruiting agency. Please also note that submission of unsolicited resumes does not create any obligations for Shattuck Labs, implied or otherwise. Note to Job Applicants: New employees will be required to be in compliance with Shattuck's EEOC-compliant COVID-19 vaccination policy.

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