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Research Associate III

Durham County, NC
Closing date
Jan 18, 2022

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Science, Pharmaceutical, Clinical Research Associate
Organization Type
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Job Description
About Us

Shattuck Labs, Inc. (NASDAQ: STTK) is a clinical-stage biotechnology company pioneering the development of bi-functional fusion proteins as a new class of biologic medicine for the treatment of patients with cancer and autoimmune disease, with three ongoing Phase 1 clinical trials. Compounds derived from Shattuck's proprietary Agonist Redirected Checkpoint, ARC®, platform simultaneously inhibit checkpoint molecules and activate costimulatory molecules within a single therapeutic. The company's SL-172154 (SIRPα-Fc-CD40L) program, which is designed to block the CD47/SIRPα checkpoint interaction and simultaneously agonize the CD40 pathway, is being evaluated in two Phase 1 trials. A second product candidate, SL-279252 (PD1-Fc-OX40L), is being evaluated in a Phase 1 trial in solid tumors or lymphomas. Additionally, the company is advancing a proprietary Gamma Delta T Cell Engager, GADLEN™, platform, which is designed to bridge gamma delta T cells to tumor antigens for the treatment of patients with cancer. Shattuck has offices in both Austin, Texas and Durham, North Carolina. For more information, please visit:

About the Position

The Research Associate 3 - Bioanalytical Method Development and Validation will be responsible for the design, development and qualification of a series of flow cytometry based receptor occupancy and immune phenotyping assays. In addition, the candidate will support the development of other cell-based potency, pharmacokinetic, pharmacodynamic, and immunogenicity assays; necessary to support non-clinical development of ARC therapeutics. This is a bench research position, but will also involve data analysis and presentation internally and at times to external CROs.

You will report to the Director of Translational Research, and work closely with the internal R&D team at Shattuck. This is a full-time position based in Research Triangle Park, NC. Shattuck will provide a competitive compensation and benefits package.

Summary of Key Responsibilities
  • Design and execute: Flow Cytometry-based receptor occupancy and immune phenotyping assays; familiarity with multicolor flow
    • Familiarity with BD systems a plus, but not required.
  • Design and execute: Mammalian cell-based potency assays using immortalized and primary cells.
    • Platform experience with time-lapse microscopy systems, luminescence/fluorescence reporter systems is highly desirable.
  • Support the development and execution of pharmacokinetic, pharmacodynamic, and immunogenicity assays; using ECL ELISA, standard ELISA, Western blot, and flow cytometry based platforms.
  • Interpret method development data from each of the above assay platforms, evaluate performance in matrix samples (where applicable), then design and execute method qualification activities for assays.
  • Evaluate significance of data and report findings.
  • Prepare study summaries, method protocols and/or reports.
  • Facilitate method transfer to CROs

Required Qualifications and Skills
  • The successful candidate will hold a degree in one of the following fields, or similar; Biochemistry, Biophysics, Molecular Biology, Immunology, Biology or Chemistry
    • B.S./B.A. degree, and candidates with M.S. encouraged to apply
    • Extensive direct experience with flow cytometry experimental design and execution, panel and marker selection highly desirable.
    • Direct experience with mammalian cell culture
  • Proven ability to collaborate with other functional areas within the company.
  • Excellent oral and written communication skills with strong technical writing experience required.
  • Able to multi-task productively, applying time management processes and procedures effectively for on time delivery.
  • Technically capable of determining what is wrong in complex situations and offering potential solutions, identifying root cause of a problem and working with others to correct problems.
  • Must enjoy working in collaboration with others and small teams to achieve goals through effective building of relationships with co-workers
  • Candidate must be sharp, self-motivated, and able to thrive in a fast-paced dynamic biotech environment where flexibility, tolerability to rapid change, and drive to make a significant impact is essential.

Note to External Recruiters: Our Human Resources department manages all open positions and candidate recruitment. We kindly ask that recruiters not contact employees or hiring managers directly to present candidates or solicit business. Please note that we will consider failure to comply with this request when determining whether to enter into a professional relationship with a recruiting agency. Please also note that submission of unsolicited resumes does not create any obligations for Shattuck Labs, implied or otherwise.

Note to Job Applicants: New employees will be required to be in compliance with Shattuck's EEOC-compliant COVID-19 vaccination policy.
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