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Principal Scientist, Biochemistry and Quantitative Pharmacology-Enzymology

La Jolla, California
Closing date
Jan 21, 2022

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Science, Pharmaceutical
Full Time
Organization Type
Jobseeker Type
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that improve patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose where we translate science and technologies into the therapies and vaccines that matter most. Whether you are in discovery, ensuring drug safety and efficacy or supporting clinical trials, you will be a key contributor to our mission of bringing best in class medicines to patients around the world.

What You Will Achieve

The Oncology Research Division in La Jolla, California is seeking a motivated and innovative Scientist to join the Enzymology group within the Biochemistry and Quantitative Pharmacology Department. The successful candidate will provide their expertise in biochemistry/ mechanistic enzymology to enable the advancement of pre-clinical programs within the Pfizer Oncology portfolio. They will gain in-depth, hands-on experience in cutting-edge drug discovery from target validation to clinical candidate nomination on diverse targets relevant to cancer.

How You Will Achieve It
  • Act as the Biochemistry and Quantitative Pharmacology lead on 1-2 research project teams
  • Develop and execute strategies to address key biochemical questions facing project teams
  • Apply deep understanding of mechanistic enzymology to understand enzyme drug targets. This includes studies related to enzyme function, regulation and specificity, determination of enzyme mechanism of action, inhibitor mechanism of action and protein/ligand SAR
  • Develop robust, automated biochemical assays to support drug discovery in the context of the project team
  • Work collaboratively with scientists in the context of the project team to answer key scientific questions and develop first-in-class medicines
  • Mentor/train other scientists
  • Actively participate on multi-disciplinary project teams. Drive our understanding of the biochemistry/biology of the target, consistently contribute to strategy discussions and decision making and effectively communicate results to the team
  • Build an internal and external reputation through presentations and publications


  • PhD in Biochemistry or related discipline with a minimum of 5 years relevant biochemistry and/or enzymology post-graduate and/or industrial experience
  • Track record of independent research evidenced by publications in top-tier journals, including a minimum of two first author publications
  • Excellent organizational skills with outstanding verbal and written communication

  • Minimum 3 years of experience in a drug discovery environment
  • Strong knowledge of the mechanisms of diverse classes of enzymes (kinases, acetylases, methylases, etc.)
  • Experience developing biophysical and/or cellular protein-ligand assays
  • Experience and/or interest in using mass spectrometry to characterize enzyme activity
  • Scientific knowledge on a specific area of emphasis for Pfizer Oncology (e.g., Ubiquitin Proteasome System, Epigenetics, Cell Cycle, Cancer Immunology)

  • Ability to execute laboratory experiments and perform complex data analyses
  • Ability to interpret results relative to published data and ongoing Pfizer programs
  • Strong interpersonal skills and a desire to succeed in a team setting
  • Willingness to work with radioactive materials (3H, 32P, 33P)


Eligible for Relocation Package

Eligible for Employee Referral Bonus

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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