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Senior Scientist, Medicinal Chemistry

La Jolla, California
Closing date
Jan 21, 2022

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Science, Pharmaceutical
Full Time
Organization Type
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  • We are seeking a creative and highly motivated synthetic organic chemist to join Pfizer's Medicine Design, Oncology Medicinal Chemistry Department in La Jolla, CA. As part of this group, the successful applicant will contribute through innovative synthetic chemistry tothedesign and deliveryof clinical candidates aligned with the Oncology Research portfolio.
  • The Medicinal Chemistry Department is one of many critical disciplines involved in small molecule drug discovery within Medicinal Design at Pfizer with experts in molecular design, synthesis, computational chemistry, structural biology, chemical biology, and analytical chemistry. As a Senior Scientist in Oncology Medicinal Chemistry you will play a vital role as a key contributor within a large, multi-disciplinary matrix team from project inception through to delivery of clinical drug candidates.
  • Discovering new medicines at Pfizer takes teams with a diversity of skills, behaviors and approaches. Creativity, scientific excellence, tenacity, passion, hard work, organization, teamwork, courage, open-mindedness, curiosity - are just some of the traits successful Drug Discoverers display at Pfizer, and we are looking for ambitious Synthetic Chemists, eager to see their work lead to important new medicines and scientific breakthroughs, to join our team.

  • Understand the goals and strategies of the project and, as part of the synthesis team, positively and proactively influence the project team through the development of innovative and practical chemistry.
  • Develop and execute innovative and practical synthetic strategies aligned to team goals, including the development of versatile and modular synthetic routes compatible with rapid new target synthesis and efficient scalable routes to preclinical drug candidates
  • Maintain a high level of productivity in the lab delivering on team goals
  • Build effective partnerships with other research lines, in particular analytical, pharmaceutical sciences, and technology groups, for the efficient delivery of target molecules
  • Collaborate with project team members to effectively transfer enabled chemistry to contract research chemists and process development where applicable
  • Engage in multi-site medicinal chemistry discussions; prepare and present research results in chemistry and project team meetings
  • Publish and present research internally and externally to Pfizer

  • Doctoral degree in synthetic organic chemistry with 0-3 years of laboratory-based research or Master's degree with 6-10 years' experience in the pharmaceutical industry
  • Expertise in methodology development and has successfully completed multistep syntheses
  • Expertise in reaction mechanisms and retrosynthetic analysis; ability to prioritize and simultaneously execute multiple synthetic options
  • State of the art knowledge of techniques related to purification and characterization of organic compounds
  • Comfortable working in a highly collaborative team environment
  • Ability to scientifically challenge others in a constructive manner and demonstrates exceptional team working skills (e.g. approachable and collaborative)
  • Proven track record of creative thinking and consistent delivery as demonstrated by publication and presentation records
  • Stays up to date with chemical literature and possess a contemporary knowledge of emerging synthetic methodologies and technologies

*Please include a research summary when submitting your formal application

  • Demonstrated ability to effectively work within a multi-disciplinary team of colleagues
  • Previous experience in mentoring and development of junior scientists or students is a plus .

  • Requires the ability to carry out experimental organic chemistry in a standard chemical laboratory

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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