Site Name: USA - Pennsylvania - Upper Providence Posted Date: Dec 15 2021 Are you energized by the challenge of shaping and accelerating the scientific expertise of a biology program? If so, this Scientific Investigator opportunity could be an exciting opportunity to consider. We are seeking a highly motivated Scientific Investigator to work on new treatments to address the threat of infectious diseases by joining our growing Infectious Diseases Research Unit (RU) focused on Infectious Diseases at Upper Providence, PA. The Infectious Diseases Research Unit is one of the Research Units in the R&D organization at GSK and is responsible for the discovery of novel approaches & targets to treat infectious diseases that threaten our health and progressing them to clinical proof of concept studies. The Research Unit has an impactful portfolio of projects in hepatitis B, bacterial infections and viral respiratory infections (including COVID-19) along with collaborations with Vir Biotechnology and 23&Me. This position functions within Infectious Diseases Research Unit and supports target validation through drug discovery and early clinical development. You would be responsible for conducting Infectious Disease related work in molecular and cell biology in the progression and advancement of drug discovery projects against respiratory pathogens and other potential viral targets. The successful candidate will have extensive knowledge and hands-on research expertise in respiratory viral disease. They will be responsible for evaluating novel targets including the design and execution of mechanism of action studies using small molecule inhibitors and/ biologics and the development and optimization of various in-vitro, in-vivo, and/or ex-vivo state-of-the art assays. The successful candidate will be science driven, familiar with most cell and molecular biology techniques and instrumentation, one who can assume personal accountability and keen to learn through experience to advance in their career. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following… Establish and validate in vitro cellular models of disease using primary human cell cultures and other cell types Define, design, and perform experiments using in vitro cellular models to evaluate molecules and or genetic modifiers (e.g., CRISPR, siRNA) to validate drug discovery targets and/or progress lead optimization project Conduct pharmacological studies characterizing effects with an array of in vitro techniques that may include immunoassays (ELISA, MSD), qRT-PCR, high-content cell imaging, confocal microscopy, and scRNAseq, among others Independently execute laboratory experiments, conduct statistically supported data analysis, and deliver results in a timely manner to enable informed decision making Contribute independently to the direction of the work, providing clear next steps for the research Clearly communicate study results and impact in written form and at internal and external meetings. Commit to continual improvement by reading and applying the latest scientific literature, methodologies, and technologies. Comply with all standards and practices of data integrity, ethics, and safety. Model GSKs values of patient-focus, respect, transparency, and integrity Define, design, and execute experiments Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Master of Science degree with 6-8+ years of relevant research experience or a PhD in cell biology or infectious disease Prior experience working with primary cell cultures and technical experience with cellular/molecular biology and immunology assays such as RNA/DNA transfection, cutting-edge genome editing technologies, scRNAseq, qRT-PCR, PCR, ELISA, Western/MSD analysis, immunofluorescence, flow cytometry. Prior experience handling and working with infectious agents. Preferred Qualifications: If you have the following characteristics, it would be a plus: PhD with >2 year post-doctoral experience in urinary tract infection or respiratory virus disease Prior experience in complex in vitro models of uroepithelial bladder or respiratory virus disease Understanding of drug discovery via previous experience in biotech/pharmaceutical projects Demonstrated leadership experience Previous experience in bacterial or virus infection models and familiarity with the microbe/host interaction landscape and immunology Prior assay development and validation experience Knowledge and experience in immunological assays to probe disease relevant mechanisms Experience with drug target evaluation and validation Knowledge of human genetics including CRISPR/siRNA/shRNA methodology for gene modulation Demonstrated productivity and impact through laboratory contributions to multiple projects Outstanding written and oral communication skills with strong track record of scientific publications Ability to adapt to changing priorities Strong work ethic with desire to carry out independent hypothesis generation and testing Highly motivated self-starter, with excellent verbal and written communication skills, and the ability to work effectively individually and in team and matrix environments Self-motivated and able to resolve technical challenges and deliver consistent results efficiently in a timely manner Effective communication (both verbal and written) of scientific ideas and results to internal groups and program teams. Skills in interpreting results and drawing conclusions through independent working and with supervision Demonstrated capability to address critical path biology activities of the research projects Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together. *LI-GSK *This is a job description to aide in the job posting, but does not include all job evaluation details. 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