Scientist, Discovery Formulation and Analytics

Wave Life Sciences is a biotechnology company focused on delivering transformational therapies for patients with serious, genetically defined diseases. We differentiate ourselves through our proprietary chemistry platform that enables the production of stereopure oligonucleotides that precisely target the underlying cause of rare diseases. At Wave, we welcome those who share a passion to change lives and embrace a culture that is thoughtful, dynamic, humble, and fearless. Together, we can contribute to our mission enabling every patient with a genetic disease to have access to life changing treatments.

Wave is looking to hire a Scientist I/II, Discovery Formulations and Analytics. This position is ideal for a scientist with a strong background in analytical chemistry who thrives in a team-oriented, fast-paced, biotech environment. The Scientist I/II will be an integral member of the oligo synthesis & process development team contributing to the preparation and analysis of oligonucleotide formulations as well as compound characterization and inventory management. This position is located at our site in Lexington, MA.

Responsibilities

• Supervise and lead a team of junior scientists in the development and preparation of oligonucleotide formulations for in vitro and in vivo experiments and ensure sample quality

• Prioritize team activities to enable timely delivery of formulations

• Perform assays using techniques such as UV, pH, osmolality, and bacterial endotoxin

• Operate and create novel methods for Hamilton liquid handler

• Analyze and evaluate oligonucleotide purity and identification by UPLC and LC/MS

• Maintain an accurate and traceable oligonucleotide inventory

• Communicate effectively with interdepartmental teams, such as discovery chemistry, synthesis and biology

• Document experimental results in ELN and register relevant sample data

• Support general laboratory function through instrument maintenance, troubleshooting and problem solving

Qualifications

• MS or PhD in chemistry or a related discipline with at least 3 years of experience in an industry environment (BS degree with 5 years of relevant experience)

• Previous experience with UPLC and LC/MS operation and analysis is strongly preferred

• Previous experience with automated liquid handler operation preferred

• Experience with data processing and calculations in Excel

• Meticulous attention to detail and data integrity

• Ability to multitask and meet deadlines

• Capable of working both independently and collaboratively

• Excellent problem-solving skills with adaptability to excel in a dynamic and shifting environment

Throughout the global pandemic, Wave has been committed to ensuring the safety of all employees and their families, while continuing to move the business forward so that we can deliver on our commitment to patients. We have implemented an approach to COVID-19 that is informed by the science and aligns to recommendations established by the CDC and other applicable government health agencies. To that end, Wave has implemented a mandatory COVID-19 vaccination policy that requires its employees to be vaccinated to the maximum extent permitted by applicable law.

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences' employees to perform their job duties may result in discipline up to and including discharge.