Scientist in Translational Immuno-Oncology

The Center for Translational Immunology and Immunotherapy, a collaborative effort between the Departments of Immunology and Bone Marrow Transplantation & Cellular Therapy (BMTCT), has recently launched, with a focus on immune monitoring of new clinical trials, efforts to define and exploit productive anti-tumor immune responses, and characterization of immune competence during standard and experimental cancer treatments.

We are seeking a Scientist to join this exciting multidisciplinary effort. As a member of the Thomas Lab, under the supervision of Dr. Jeremy Chase Crawford, your research will support our comprehensive efforts to study anti-tumor immunity and develop novel, immune-based treatments while collaborating with scientists, clinicians, and bioinformaticians across the institution.

In addition to applying cutting-edge techniques (like single-cell and spatial transcriptomics) to patient samples, you will have opportunities to help develop novel molecular and cellular approaches, pushing the boundaries of current laboratory capabilities. 

The ideal candidate will be highly motivated and detail-oriented with an interest in immunology and immunotherapy, and have excellent laboratory, data curation, and critical thinking skills.  

Experience with flow cytometry, PCR, NGS library preparation, molecular cloning, and cell culture is preferred. Experience with single-cell genomics and/or spatial transcriptomics is beneficial but not required. Excellent communication and organization skills are required, as you will play a major role in coordinating research efforts among various labs within the institution. In addition, the ability to work as a team player and collaborate effectively is essential for this position.

Responsibilities

This position will be primarily dedicated to processing patient samples with single-cell genomics and T cell receptor sequencing assays for ongoing immunotherapy clinical trials. Outside of this primary responsibility, there will be numerous opportunities to participate in other complementary research endeavors, including the development of novel wet lab approaches and the development and application of spatial transcriptomics techniques. This position entails working closely with key stakeholders and managing a wet lab environment and corresponding equipment.

To include:

• Organizing, handling, and processing patient samples in a timely manner

• Developing and following Standard Operating Procedures

• Carefully documenting all work

• Working with CAR-T Immunotherapy clinical trials

• Running the wet lab portion of the lab under the support and guidance of Dr. Crawford

• Working closely with Departments of Immunology and BMTCT

Apply to be a part of the mission of St. Jude Childrens Research Hospital: to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. Consistent with the vision of our founder Danny Thomas, no child is denied treatment based on race, religion or a familys ability to pay.

Minimum Education

• Bachelors degree in relevant scientific area is required.

• PhD preferred

Minimum Experience

• Seven (7) years of relevant post-degree work experience is required

• Five (5) years of relevant post-degree work experience is required with a Masters degree

• Three (3) years of relevant post-degree work experience is required with a PhD

• Experience in Single-Cell Genomics, Spatial Transcriptomics, and Translational Research on Clinical Immunotherapy Trials preferred