Principal Scientist Protein Kinases

St. Jude Children's Research Hospital
Bo Bo, IN
Closing date
May 27, 2022

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Organization Type
We are seeking a highly driven scientist with broad interest in protein kinases, to oversee, organize and coordinate the activities of multiple researchers in a dynamic, comprehensive, inter-disciplinary initiative at the Department of Structural Biology, St. Jude Childrens Research Hospital.

The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 370, eabc2754, 2020) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. This strategy will be integrated with and complemented by data-science and computational approaches developed by the Babu lab (Nature 587, 650, 2020), to systematically characterize the conformational landscape of the human kinome.

We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases. We are looking for an enthusiastic scientist to join this project and take a key organizational role.

This is a high-level staff position, and the Prinicipal Scientist will:

• Oversee the activities of over 40 scientists across different teams performing biochemistry, NMR and computational analyses of different kinases.

• Organize and integrate the data generated by those teams.

• Be the contact point for PIs and team leaders for information on all ongoing projects.

• Identify kinases of biological and medical interest as targets

• Search and synthesize the relevant literature information on kinase biology as necessary.

• Prepare written materials for reports, presentations and publications.

• Take a lead on organizing internal and international scientific meetings

• Interact with other teams within St. Jude to identify scientific opportunities relevant for the project

Furthermore, the ideal candidate should have a track-record of exceptional organizational and problem-solving skills; outstanding communication skills; be able to absorb, synthesize and integrate different types of information; work independently; and thrive on a highly collaborative and fast-moving environment.

Minimum Education

• Bachelors degree in relevant scientific area is required

• Ph.D. preferred

Minimum Experience

• Fifteen (15) years of relevant post-degree work experience is required

• Thirteen (13) years of relevant post-degree work experience is required with a Masters degree

• Eleven (11) years or relevant post-degree work experience is required with a PhD.

• Prior experience in structural biology, bioinformatics and/or data management are all highly desirable.

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