High Throughput Screening Scientist

St. Jude Children's Research Hospital
Bo Bo, IN
Closing date
May 21, 2022

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Organization Type
The High Throughput Bioscience (HTB) Center at St. Jude under Director and St. Jude Faculty Member Dr. Taosheng Chen, seeks a senior Biochemist/Biophysicist or Cell Biologist/Chemical Biologist to design and implement high throughput screens:

• Biochemist/Biophysicist: high throughput direct binding assays to measure compound-target interaction from medium (as secondary assays)- to large-scale (for primary screens)

• Cell Biologist/Chemical Biologist: cell-based phenotypic screens, ranging from large-scale automated cytotoxicity screens, medium-scale genetic loss-of-function siRNA screens, to focused high-content imaging-based screens

The ideal candidate is familiar with high throughput screening and associated data analysis and quality control, and capable of developing/utilizing novel bioassays to solve challenging biology problems. The HTS Scientist reports to the Director of HTB Center and is expected to independently lead and implement collaborative projects; present or publish research results; and assist the Center Director in managing the daily operation of the Center. The HTB Center consists of those with advanced training in biology, chemistry, and engineering who work together on target identification and validation, assay development, laboratory automation, high-throughput and high-content screening (up to 600K small molecules and genome-scale siRNAs), large-scale data processing, and management of scientific collaborations.

Minimum Education

• Bachelors or Masters degree in biology, chemistry, or a related field required.

• PhD in biological sciences with relevant postdoctoral training preferred

Minimum Experience

• Experience with assay development and high-throughput screening is required. Experience in one or more of the following areas is a plus: automation, data management, protein biochemistry, biochemical and biophysical assays, high-content screening or RNAi technology, and a strong publication record

• Seven (7) years of relevant post-degree work experience is required with a Bachelors degree.

• Five (5) years of relevant post-degree work experience is required with a Masters degree

• Three (3) years of relevant post-degree work experience is required with a PhD

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