Site Name: USA - Pennsylvania - Upper Providence Posted Date: Apr 11 2022 The Investigator will be part of a drug discovery research team in Novel Human Genetics Research Unit at GSK R&D. This team focuses on the design and execution of preclinical studies to develop novel medicines for the treatment of chronic neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and Amyotrophic Lateral Sclerosis (ALS). In this role, the candidate will have the opportunity to contribute to preclinical campaigns by designing and performing in vitro and biochemical experiments to support molecule optimization and mechanism of action studies. The individual hired for this position will be a technical expert in custom in vitro and biochemical assay development and will have strong knowledge of RNA to protein structure-function relationships. This role will provide YOU the opportunity to lead key activities to progress YOUR career; these responsibilities include some of the following… Design and characterize custom cell lines and iPSC-derived cell models either independently or in collaboration with CROs and other team members Perform cellular experiments to gain understanding of protein structure-function relationships Develop custom qRT-PCR, ELISA and MSD assays to measure target/pathway engagement and to be implemented as preclinical biomarker assays Independently execute laboratory experiments, conduct statistically supported data analysis and deliver results in a timely manner to enable informed decision making Contribute to technical workplan discussions to support preclinical programs advancing from lead identification to lead optimization Clearly record and communicate study results at internal and external meetings Commit to continual improvement by reading and applying the latest scientific literature, methodologies and technologies Comply with all standards and practices of data integrity, ethics, and safety Model GSK's values of patient-focus, respect, transparency, and integrity Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: MSc and expert-level knowledge of cell biology, biochemistry and neuroscience. 3+ years pharmaceutical or biotechnology industry experience. An ability to independently design, execute and interpret high-quality experiments is essential. Preferred Qualifications: If you have the following characteristics, it would be a plus: PhD Technical expertise in molecular construct design, custom cell line generation and validation, novel antibody validation, ELISA/MSD assay development, immunoprecipitation and quantitative RT-PCR is highly desired. Prior experience performing in vitro pharmacology experiments to evaluate small molecules, antibodies and oligonucleotides. Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together. *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. 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