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Scientist II, Antibody and Small Molecule Characterization

Position located Cambridge, MA

Responsibilities of the Scientist II, Antibody and Small Molecule Characterization:

Lead development of analytical assays for biochemical and biophysical characterization of lentiviral vectors, plasmids, and residual impurities
Lead the generation and life cycle management of critical reagents to support our broad range of programs
Perform all stages of antibody and detection reagent preparation including dye conjugation, purification, analytics, and supporting stability assessments
Support assay qualification activities and interact with CMOs and other vendors as a subject matter expert on an as needed basis
Assume responsibility for the generation, review and approval of SOPs and technical protocols/reports and preparing scientific presentations
Support analytical sections of regulatory filings

Requirements of the Scientist II, Antibody and Small Molecule Characterization:

A Ph.D. in biochemistry, analytical chemistry, or related discipline with 2-4 years of relevant industry experience
Experienced with LC/MS characterization of protein samples, especially for antibodies/antibody conjugates as well as with antibody purification and characterization
Hands-on experience with protein conjugation, purification, characterization, and immunoassays using techniques like HPLC, ELISA, gel electrophoresis, cIEF, flow cytometry etc.
Experience conducting stability studies
Expertise in design, execution, and troubleshooting of protein conjugation and analytics processes
Familiar with and passionate about supervising and/or mentoring lab personnel, thrive in a cross-functional environment and drive projects to successful outcomes

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