Postdoctoral Fellow

We are seeking to recruit two self-motivated postdoctoral fellows with a strong foundation in molecular and cellular biology and/or bioinformatics to work on translational research projects focused on hematologic malignancies. Prior experience in hematology research is a plus, but not a requirement. Applicants from abroad will be considered, including those wishing to escape from armed conflict or political oppression.

We use genetically modified mice, patient cells, and cell lines to model leukemia and apply a broad armamentarium of techniques to study signal transduction, genetics, and metabolism. We are currently funded by 2 R01s, 1 R01-like supplemental award, 1 R21, 1 DOD grant, and a large start-up package.

We provide advanced postdoctoral training in scientific method, writing, oral presentation skills and grantsmanship. We expect postdocs to drive projects with a high level of independence, seeking guidance when needed. These are not positions to acquire basic technical skills. We emphasize scientific rigor, attention to detail and hard work, but also transparency, fairness and integrity. We believe in team science, giving credit to all who contribute to the work. Most of our postdocs have remained in science, and many are now leading their own independent research programs in prestigious academic institutions.

Ongoing projects include:

• Developing a cellular immunotherapy for chronic myelomonocytic leukemia (CMML)
• Delineating how SIRT5 regulates metabolism in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
• Discovering a SIRT5 inhibitor using high throughput screening and quantum physics-based approaches
• Understanding the role of MS4A3 in normal and leukemic hematopoiesis
• Mapping the ecosystem of chronic myelomonocytic leukemia
• Mapping clonal structure in aggressive systemic mastocytosis
• Understanding resistance to BCR-ABL1 compound mutations in chronic myeloid leukemia

We encourage our lab members to think out of the box, ask critical questions, and participate actively in discussions. Creativity and innovation thrive in environment where people like to work, feel respected, and can realize their full potential. If you I hear yourself say: "OMG, Milwaukee" and "what the heck is this Blood Research Institute", then you should write to me.

Michael Deininger MD PhD

Director, Blood Research Institute

Professor of Medicine, Medical College of Wisconsin