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Senior Scientist

Employer
National Institutes of Health
Location
Clayton, MO
Closing date
Jun 6, 2022

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Sector
Science
Organization Type
Corporate
Position Description:
Vir Biotechnology is a commercial-stage immunology company focused on combining immunologic insights with cutting-edge technologies to treat and prevent serious infectious diseases. Vir has assembled four technology platforms that are designed to stimulate and enhance the immune system by exploiting critical observations of natural immune processes. Its current development pipeline consists of product candidates targeting COVID-19, hepatitis B virus, influenza A and human immunodeficiency virus.
We believe the success of our colleagues drives the success of our Mission. We have an ongoing commitment to creating a company passionate about equality, inclusion, and respect. When everyone feels supported and encouraged to give at their best, we will collectively deliver outstanding results.
Job Summary:
Vir Biotechnology is seeking an experienced and motivated Senior Scientist to join our DMPK team. Reporting to the Head of DMPK, this role will participate in discovery and translational research efforts aimed at characterizing the ADME/PK properties of small and large molecules. The Senior Scientist will be an integral part of a highly collaborative group, working closely with discovery and development teams such as Medicinal Chemistry, Pharmacology, Structural Biology, Toxicology and Clinical Pharmacology. The Senior Scientist will lead the design, management and sample bioanalysis from in vivo PK studies, as well as represent DMPK in project teams, while taking an active role in project team strategic discussions.
Responsibilities And Learning Opportunities:
  • Evaluate the PK properties of our drug candidates by selecting, designing and managing in vivo studies (in-house or outsourced) as well as overseeing and participating to the sample bioanalysis.
  • Analyze, summarize, interpret and present study results to project teams.
  • Ensure adherence to the highest quality standards and quick turnaround times.
  • Maintain up-to-date knowledge in advancements in DMPK, and apply to the development of new capabilities/strategies where appropriate.
  • Keep quality electronic records and upload data into company databases.
  • Build, manage and mentor a small team of Junior members.
  • Author reports and documents in support of regulatory filing efforts.
  • Be a key DMPK contributor in multidisciplinary team meetings by providing subject matter expertise to help advancing drug candidates through discovery and development.

Qualifications:
  • PhD in a relevant field with 4+ years' industry R&D experience, MS with a minimum of 8+ years of experience, or BS with a minimum of 10+ years preferred.
  • Demonstrated hands-on experience with small molecule quantitative bioanalysis by LC/MS, as well as PK data analysis and reporting
  • Familiarity with DMPK techniques, methodologies and workflows; clear understanding of ADME/PK principles and strategies in drug discovery and preclinical development.
  • Knowledge and experience with discovery-level compound formulation a plus.
  • Track record of Research Associates management.
  • Experience with supporting regulatory activities.
  • Complex problem solving- and analytical skills, critical thinking, strive for scientific excellence.
  • Excellent communication and organizational skills; attention to detail while working in a fast-paced environment.
  • Familiarity with PK/PD analysis as well as biopharmaceuticals desirable but not required.

Vir's compensation and benefits are aligned with the current market and commensurate with the person's experience and qualifications. All full-time employees receive a package that includes compensation, bonus and equity as well as many other Vir benefits and perks such as health, dental, vision, life and disability insurance benefits, non-accrual paid time off, one Friday a month paid-time off, company shut down for holidays, commuter benefits, child care reimbursement, education reimbursement, 401K match and lunch for all lab essential personnel!
Vir is an equal opportunity employer. We value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform critical job functions, and to receive other benefits and privileges of employment. Please contact Human Resources to request accommodation.
Vir Human Resources leads recruitment and employment for Vir. Unsolicited resumes sent to Vir from recruiters do not constitute any type of relationship between the recruiter and Vir and do not obligate Vir to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees.

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