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Staff Bioinformatics Scientist

Thermo Fisher Scientific
Ann Arbor, MI
Closing date
Jun 24, 2022

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Do you have a passion for innovative ideas and groundbreaking discoveries? With over $1 billion invested annually in R&D, at Thermo Fisher Scientific, we empower our teams to put science into meaningful action and give our R&D colleagues the autonomy, resources and tools they need to take science a step beyond. Next-Generation Sequencing (NGS) is rapidly reshaping life sciences, translational research, and clinical diagnostics. We are dedicated to improving the quality of sequencing and broadening the range of its applications.

Location/Division Specific Information:

The position is based in Ann Arbor, MI and is part of the extended Bioinformatics team within the Clinical Next-Generation Sequencing Division. The mission of this business unit is to develop next-generation sequencing based solutions to support applications in oncology and other medical fields.

How will you make an impact?

You will join a team of hard-working engineers and scientists, passionate about bringing actionable insights to precision oncology. The successful candidate will work collaboratively in a matrix environment to develop data analysis strategies to address key questions about cancer for our internal and external customers. Applications include diagnostics, target and biomarker discovery, indication selection, and clinical development strategies.

We are seeking individuals with expertise in bioinformatics and an understanding of the cancer genome to identify relevant cancer driver aberrations. Motivated and innovative bioinformatics scientists seeking to advance in these fields are encouraged to join our NGS R&D Bioinformatics team.

What will you do?
  • Your primary responsibility is to lead or support new product introductions (NPI), focusing on sequencing and analysis strategies for somatic oncology applications.
  • You will deliver analyses for small variant discovery, variant calling, CNV detection, and fusion calling. In addition, you will analyze complex biomarker signatures including microsatellite instability, tumor mutation burden and homologous recombination deficiency. You will interpret analyses, summarize results, and share findings with appropriate teams.
  • Additional responsibilities include providing support for on-market products and finding opportunities for continuous improvement
  • You will develop standard methodologies and innovative solutions with your colleagues in bioinformatics, learning from each other in a collaborative environment.
  • You will work closely with other R&D scientists in molecular biology, software, instrument and program management. You will partner with product management to understand customer needs.
  • You will understand and follow product development process guidelines around design, development, and testing.
  • You will play a pivotal role in algorithm and tool development, translating new product requirements into prototype and production-level software, testing and integrating your code, and coordinating improvements.

You will remain up to date with the latest developments in high-throughput genomics and oncology informatics. You may engage with collaborators or users, and you may attend and present at scientific meetings as appropriate.

How will you get here?

Education / Experience:
  • PhD degree in bioinformatics, computational biology, statistics, computer science, or biological sciences, with 2+ years of experience, (or MS with 5+ years) with experience in oncology preferred, or in a related area such as inherited disease or human genetics.
  • Familiarity with public cancer genomic data sources such as TCGA, COSMIC, and ClinVar is required.
  • Track record of productivity including scientific publications, conference presentations, and product development will make you a stronger candidate.

Knowledge, Skills, Abilities:
  • Proven knowledge of next-generation sequencing analysis, with good understanding of software engineering and data analysis principles.
  • Proficiencies in a scripting language (Python preferred or Perl), a statistical package (R preferred or MATLAB), and shell-scripting are required.
  • Computational pipeline development and database management, as well as proven background in genomics and statistics.
  • Effective communication skills, especially for presenting scientific results, working collaboratively in a team, and documenting work.
  • Ability to work in a multi-disciplinary and geographically distributed team environment.
  • Strong drive for problem-solving and continuous improvement, with the perseverance to work through obstacles.

Full robust benefits and US Domestic relocation available for qualified candidates.

Our global team of more than 100,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services and Patheon. For more information, please visit .

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.
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