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Assistant Research Scientist

New York State Psychiatry Institute
Grand Central, NY
Closing date
Jun 25, 2022

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The Research Foundation for Mental Hygiene, Inc. is seeking a highly motivated and qualified candidate for a full-time Assistant Research Scientist (ARS) position in the Division of Molecular Therapeutics. The ARS will be involved in projects focused on understanding the molecular determinates of G Protein-Coupled Receptor (GPCR)-mediated effector activation and interactions using single-molecule microscopy in living cells. The qualified candidate will work closely with division members including undergraduate and graduate students, postdoctoral and senior research scientists, and faculty members. Analysis of GPCR signaling using kinetic models to quantify concentration-time-dependent parameters of GPCR activity is also desirable, as is proficiency with associated data analysis software platforms (GraphPad Prism, R, MatLab, etc.). A track record of working effectively across experimental and computational groups, and demonstrable previous collaborative success is essential.

Duties and Responsibilities:

The ARS will work with a team of division researchers to develop and characterize single-molecule fluorescence imaging-based assays for probing -arrestin and GPCR kinase (GRK) interactions with, and activation by, different classes of GPCRs at the plasma membrane of living cells. The candidate will use these methods to understand how heterogeneity in GPCR--arrestin and/or -GRK interactions and kinetics relate to receptor ligand efficacy, GPCR phosphorylation status, and organization and diffusion in the plasma membrane of living cells. The ARS will use standard methods in molecular biology for construction of expression plasmids coding for receptors and their effectors tagged with fluorescent protein and/or self-labeling tags for imaging purposes. Ensemble and/or bulk cell-based assays (ELISA, Immunocytochemistry, fluorescence, and energy transfer-based assays) will also be performed by the candidate as complementary approaches as well as to validate observations made at the single-molecule level. The candidate is additionally responsible for communicating with and mentoring other lab members in the development and deployment of such assays in addition to fostering any necessary collaborations. The researcher is also responsible for developing and performing experiments and analysis strategies alongside other members of the lab, preparing results for presentations, writing manuscripts for publishing, and contributing to broader aspects of collaborative projects in the lab.

Minimum Qualifications:

PhD or equivalent degree in molecular pharmacology, biophysics, or related fields

2 years postdoctoral experience.

Candidates who have fulfilled all doctoral degree requirements but have yet to receive their degree will also be considered and are encouraged to apply; such candidates must have the doctoral degree conferred by the start date of the position.

2 years of experience with in vitro and/or in vivo pharmacology of GPCRs, particularly in understanding -arrestins and GRKs interactions with receptors, as evidenced by relevant publications in the field.

2 years of experience using sterile mammalian cell culture techniques and familiarity with high-content imaging and immunocytochemistry.

2 years of previous experience with biophysical sensors of GPCR activity, including their development (using molecular cloning techniques), and optimization is advantageous.

Preferred Qualifications:

Personal or professional experience engaging with minoritized populations in the United States; record of scholarly publication, including first-authored scientific journal articles; expertise in research design and data analysis, including both quantitative and qualitative; demonstrated track record engaging with stakeholders including study participants, clinicians, community members, and researchers; prior supervision of research team or coordination of research activities; current knowledge of mental health problems and services in the United States; knowledge, expertise and/or interest in implementation science research methods; bilingual English/Spanish

In accordance with NYS Office of Mental Health regulations, RFMH employees are required to be fully vaccinated .

Work Location: 1051 Riverside Dr. NY, NY 10032

To Apply: Submit an application through our website by June 15, 2022, at: Please note, only applications submitted through our website will be considered.

The Research Foundation is a private not-for-profit corporation and is not an agency or instrumentality of the State of New York. Employees of the Research Foundation are not state employees, do not participate in any state retirement system, and do not receive state fringe benefits. Excellent Benefits Package. Employer/Minority/Women/Disabled/Veteran Employer. VEVRAA 41 CFR 60-300.5(a) compliant.
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