Senior Research Fellow - Cancer Sciences

Employer
University of Southampton
Location
Southampton, United Kingdom
Salary
£39,739 to £44,706
Closing date
Jul 1, 2022

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CRUK ECRIN-M3 Senior Postdoctoral Research Fellow in B-cell Cancer Bioinformatics

The School of Cancer Sciences, with over 100 scientists, bioinformaticians, clinicians, and associated staff, has a long and distinguished international record in the study of B-cell cancers.

We are now seeking a senior research computational scientist to investigate bulk and single-cell gene expression, and chromatin accessibility in normal and malignant immune cells, as part of the international CRUK Accelerator 'Early Cancer Research Initiative Network on Monoclonal B-cell Lymphocytosis' (ECRIN-M3) programme grant awarded to Professor Francesco Forconi with Professors Jonathan Strefford, James Batchelor, Freda Stevenson, and EU partners from Spain and Italy.

The successful candidate will have extensive bioinformatics experience on genomic, transcriptomic, epigenomic next-generation sequencing (NGS) data, and high-level data integration. They will work within a dynamic, productive and friendly team of bioinformaticians, immunologists, geneticists, molecular/cellular biologists and clinical scientists, investigating the biology of early-stage mature B-cell cancers, and will analyse NGS-based expression and ATAC-seq data at the bulk and single-cell level, with subsequent downstream modelling and molecular studies. They will ultimately aim to identify patterns determining B-cell cancer progression, highlighting potential early cancer biomarkers.

This project offers the opportunity to develop a wide range of NGS and bioinformatics and provides the prospect of collaborative work with national and international opinion-leaders in the areas of computational methods for the analysis of high-throughput RNA and ATAC-seq data. Your work will have important implications for the clinical management of patients, including the development of better methods of patient stratification.

This post will be based within the School of Cancer Sciences, Centre for Cancer Immunology and Clinical Informatics Research Unit (CIRU) at the Southampton General Hospital, occupying modern, well-equipped, purpose-built laboratories, with support from clinical and laboratory-based colleagues.

The position is funded by Cancer Research UK and is full-time, fixed-term to August 2025.

We aim to be an equal opportunities employer and welcome applications from all sections of the community. EU and international applications are also welcome. If a sufficient number of applications are received this vacancy may close earlier than the date specified at the top of this advert. Therefore, if interested in applying for this vacancy we recommend you submit your completed application as soon as possible.

Additional details about the School of Cancer Sciences can be found at https://www.southampton.ac.uk/medicine/academic_units/academic_units/cancer_sciences.page

Informal queries should be directed to Professors Francesco Forconi ( f.forconi@soton.ac.uk ), Jonathan Strefford ( jcs@soton.ac.uk ) and/or James Batchelor ( J.Batchelor@soton.ac.uk ). Please quote reference 1868322CM on all correspondence.

We aim to be an equal opportunities employer and welcome applications from all sections of the community.

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