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Head Of Chemistry

Employer
BridGene Biosciences, Inc.
Location
San Jose, CA
Closing date
Jul 8, 2022

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Sector
Science, Chemistry
Organization Type
Corporate
Head of Chemistry

BridGene is a biotechnology company focused on discovering and developing innovative small molecules that drug traditionally undruggable targets, providing new paths to treat diseases. By using its proprietary chemoproteomic platform, IMTAC™, BridGene can screen small molecules against all proteins in live cells to discover drug candidates for high-value and previously undruggable targets. For this purpose, BridGene takes advantage of its proprietary, diverse library of tagged, drug-like small molecules. The ultimate goal is to enable breakthrough small molecule drug discovery and to expand the mechanisms to treat diseases, with targets previously inaccessible to small molecules. BridGene is advancing a diversified pipeline of first-in-class drugs for targets in multiple disease areas.

We are looking for a creative and highly motivated chemistry leader with an eye for innovation to join our diverse, talented, collaborative, reliable, and explorative team as the Head of Chemistry. The Chemistry head will serve a principal role at BridGene to lead a team of internal and external medicinal chemists in all phases of the drug discovery process, including optimizing and advancing novel compounds into clinical development and IND submission.

This is a fantastic opportunity to join a fast-paced company in an exciting new biotechnology field and use cutting-edge science to tackle unmet medical needs. We will work together to build a great, science-driven biopharmaceutical company.

Responsibilities
  • Lead drug discovery and development programs
  • Discover and advance novel small molecule drugs into clinical development
  • Contribute to overall corporate medicinal chemistry strategy. Implement and execute medicinal chemistry strategies to deliver high-quality clinical candidates
  • Guide biological testing, ADME characterization, and other lead profiling assays; Develop compound optimization strategies, leveraging structural and computational insights, to improve key drug attributes
  • Lead and manage CRO activities, providing synthetic expertise
  • Contribute to the writing of patent applications, study reports, and scientific publications.
  • Keep up to date with the latest scientific advances in technologies and trends in medicinal chemistry research and development to deliver the next-generation therapies
  • Collaborate effectively with other departments and functions to advance research programs expeditiously from discovery to clinical candidate


Qualifications
  • Ph.D. in synthetic organic or medicinal chemistry with 12+ years of drug discovery experience in a pharmaceutical and/or biotechnology setting
  • Proven track record in medicinal chemistry by successful advancement of drug discovery projects from hit to lead and lead to clinical candidate nomination
  • Strong expertise in establishing and executing medicinal chemistry strategies across all stages of drug discovery to achieve program goals
  • Medicinal Chemistry expert with an excellent understanding of biology, pharmacology, DMPK, and the ability to integrate these disciplines toward successful project progression
  • Extensive project leadership experience bringing teams through lead optimization and selection of development candidates
  • Demonstrated success in the development of covalent small molecule drugs highly preferred
  • Extensive experience in managing external CRO chemistry teams
  • Clear and effective communication skills to present project strategy and progress to internal colleagues and external collaborators
  • Ability to make key decisions and manage timelines/resources to advance programs, creative problem-solving skills, and multi-tasking skills
  • Strong interpersonal, teamwork, communication, and organizational skills, and ability to thrive in a dynamic, fast-paced, innovative environment.


BridGene Biosciences, Inc. is located in San Francisco Bay Area, California. For immediate consideration, please send your CV to hr@bridgenebiosciences.com

BridGene Biosciences is proud to be an equal opportunity employer and will consider all qualified applicants for employment.

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