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Research Associate - In-vitro Metabolism (LCMS focus)

Madison, WI
Closing date
Aug 6, 2022

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We are seeking an experienced LCMS scientist to join our In-vitro Drug Metabolism team in Madison, WI. Be a part of this life-saving work. Help improve patients' lives while advancing your career.

Sign-on Bonus: $4,000 (paid around the third month of employment; external applicants only)

The ideal candidate will have experience working within a DMPK (in vitro) lab or Bioanalytical lab. The candidate will have in-depth knowledge and proven success using mass spectrometry (LCMS/MS) to analyze biological matrices and developing methods.

Duties and Responsibilities:
  • Sound understanding chromatography principles and able to troubleshoot difficult compounds.
  • Sets up and performs a variety of analyses using appropriate instrumentation with routine and non-routine methods.
  • Critically review study protocol in primary area of work and suggest changes where appropriate.
  • Provides input and participates in study meetings (i.e. pre-initiation meeting).
  • Maintains study documentation in compliance with regulatory guidelines.
  • Reviews own work for overall accuracy, timeliness, completeness, and soundness of technical judgment.
  • Deliver results within agreed timeframe, whilst recognizing changes in priorities
  • Routinely support studies in non-primary area of work
  • Ability to write, review and revise standard SOPs related to primary area of work.
  • Ability to conduct most processes/task in support of broad portfolio of study types
  • Proficient in use of department specific software
  • Participate in QC review of selected routine data and methodology section within reports within scope of current role
  • Ability to prepare results and presentations based on the work performed
  • Evaluates data for experiment modification and contribute to report preparation/review
  • Participate in method development and validation projects
  • Maintains a clean and safe laboratory work environment and perform routine maintenance.

  • Minimum Bachelor's degree in biology, chemistry or an equivalent scientific discipline. PhD or Master's degree preferred.
  • Experience may be substituted for education.
  • Minimum of 4 years' experience performing LCMS/MS analysis and developing analytical methods for small and/or large molecules including peptides, oligonucleotides, and mRNA in support of in vitro and in vivo samples.
  • Experience using AB Sciex and/or Agilent QQQ mass spec platforms preferred. High resolution mass spec (HRMS) experience is a plus.
  • Experience performing in vitro drug-drug interaction (DDI) assays including cytochrome P450 inhibition and/or induction, CYP phenotyping, transporters, plasma-protein binding, blood-plasma partitioning and metabolic stability is preferred, but not necessary.
  • Experience using Hamilton liquid handling system (Starlet, Microlab Star, etc.) platform is preferred, but not necessary.


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