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Research Technicians - Tye Lab

Howard Hughes Medical Institute
San Diego County, CA
Closing date
Aug 6, 2022

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Pharmaceutical, Laboratory
Organization Type
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Primary Work Address: 10010 North Torrey Pines Road, La Jolla, CA, 92037

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HHMI is currently seeking 3 enthusiastic, self-motivated Research Techniciansfor a full-time opportunity to join the lab of Dr. Kay Tye at the Salk Institute for Biological Studies in San Diego, CA.

The Tye lab employs a multi-disciplinary approach including optogenetic, in vivo, and ex vivo electrophysiological, pharmacological, and imaging techniques to find mechanistic explanations for how emotional and motivational states influence behavior, both in health and disease. For more information about the Tye lab and their research, please visit

As a Research Technician, you are an organized, responsible, teamwork-oriented individual who can work collaboratively with graduate students, postdocs, other technicians, and the lab manager to help facilitate daily laboratory tasks and transformative science in support of the lab's research goals. You will be responsible for performing various behavioral and systems neuroscience techniques, mouse handling, mouse colony maintenance, and assisting with general laboratory maintenance. This is an excellent opportunity for a recent college graduate who would like to gain additional years of hands-on research/laboratory experience and take advantage of various professional and skill development opportunities before moving on to graduate school.

Principal Responsibilities:

Behavioral and Systems Neuroscience Techniques (50%)
  • Mouse husbandry
  • Mouse survival surgery
  • Rodent behavioral assays
  • Optogenetics
  • Single-cell resolution calcium imaging
  • Tissue processing for histology

Data Analysis (40%)
  • Behavioral scoring
  • Neural data processing

Lab Support (10%)

Alongside other lab team members, you will:
  • Assist with inventory of lab supplies
  • Assist with stocking and organizing incoming lab supplies
  • Assist with preparing standard media and solutions
  • Assist with other support duties relating to lab operations as needed.

You Have
  • A bachelor's degree in the biological sciences.
  • Previous hands-on experience working as a technician or research assistant in a laboratory.
  • Experience with general lab maintenance, including cleaning and stocking inventory.
  • Preferably, previous experience with rodent handling.
  • Previous experience with systems neuroscience techniques would be a plus.
  • Excellent verbal and written communication skills.
  • Excellent organizational skills, time management skills, and attention to detail.
  • Proficient computer skills (PC and/or Mac, Microsoft Office Suite, etc.). Any proficiency with software applications used for research/recording/analysis or working knowledge in programming languages such as Python or MATLAB would be a plus.

You Are
  • Comfortable and willing to work with and handle live mice on a regular basis.
  • An excellent problem solver with the ability to learn complex tasks effectively.
  • Self-motivated and able to work well both independently and as part of a team.
  • Eager to learn new techniques and expand your scientific knowledge.
  • Able to interact positively with all levels of staff.
  • Able to work efficiently and be adaptable to shifting priorities.
  • Able to work an adjusted schedule outside of core 9:00am-5:00pm business hours on an occasional basis to support lab experiments as needed.

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances.

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job's principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word "may," the Essential Duties and Responsibilities described above are "essential functions" of the job, as defined by the Americans with Disabilities Act.

Compensation and Benefits

Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more.

HHMI is an Equal Opportunity Employer
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