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Senior Associate Scientist, LCMS Biomeasures

Andover, Massachusetts
Closing date
Aug 12, 2022

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Science, Pharmaceutical
Full Time
Organization Type
Jobseeker Type
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Why Patients Need You

Everything we do, every day, is in line with an unwavering commitment to the quality and the delivery of safe and effective products to patients. Our science and risk-based compliant quality culture is flexible, innovative, and customer oriented. Whether you are involved in development, maintenance, compliance or analysis through research programs, your contribution will directly impact patients

What You Will Achieve as a Senior Associate Scientist, LCMS Biomarker and Biomeasures Group

Are you a bioanalytical scientist and interested in contributing to transformative mRNA/LNP and gene therapy projects? Join us as a Senior Associate Scientist in the Biomeasures LCMS team in Pfizer Andover, MA. You will be contributing to the development and implementation of tissue based bioanalytical assays that use state-of-the-art targeted proteomic end point detection to quantify transgene protein expression in mRNA/LNP and gene therapy biodistribution studies. This is an opportunity to leverage your expertise in sample preparation, automation and bioanalysis of biologicals matrices with emphasis on tissue-based bioanalysis. You will participate in all phases of mass spec laboratory operations including the development of sample preparation methods, assay execution, instrument maintenance and data analysis. This is a great opportunity to impact an exciting new area of science and learn this is rapidly expanding field.

How You Will Achieve It
  • Responsible for developing tissue based sample preparation techniques to support gene therapy transgene and LNP biodistribution studies using state-of-the-art LCMS technology and other automation.
  • As a strong collaborator and based on demonstrated project impact, develop deep partnerships in a matrix environment.
  • Participate in technology development and implementation by exploring novel concepts and innovative workflows to expand the group's biomarker bioanalytical capabilities.
  • Participate in all phases of mass spectrometry laboratory operations including instrument maintenance, the development of sample preparation and separation methods, data analysis.
  • Ensure all tasks and responsibilities are carried out according to scientific and ethical standards e.g. responsible for eWorkbook record keeping; QC and peer review of data and/or reports.


  • BS/BA with 3+ years bioanalytical experience, ideally mostly in industry OR a MS degree with 0+ years of experience
  • General familiarity with LCMS technology and bioanalytical chemistry quantification assay development.
  • Familiarity in operation of LCMS instrumentation and associated data analysis software.

  • Expertise in quantitative tissue bioanalysis and extraction of large molecule methodology.
  • Experience in the operation and troubleshooting of LCMS instrumentation and associated operating/data analysis software including Skyline, Analyst and Xcalibur.
  • Expertise in biological sample preparation techniques (immunoaffinity, tryptic digestion, tissue processing, conjugation, etc) of various biofluids
  • Some understanding of protein biochemistry.
  • Ability to work both independently and as part of a team, multitasking multiple programs.

  • As appropriate for lab based role.

  • Lab based position requiring to perform all typical laboratory related activities
  • Based in Andover
  • Occasional travel to Cambridge (Kendal Square) may be required, depending on project needs

Other Job Details:
  • Last Date to Apply for Job: August 12th, 2022
  • Work Location Assignment: On Premise colleagues work in a Pfizer site because it's needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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