Director/Sr. Director, Translational Research

Thank you for your interest in a career at Senti Biosciences. Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases in ways previously inconceivable. We are passionate about designing gene circuits to improve the "intelligence" of cell and gene therapies in order to enhance their therapeutic effectiveness against a broad range of diseases that conventional medicines are unable to address.

At Senti, we find purpose and meaning knowing that our efforts have the potential to improve the lives of patients and their families with more effective and safer treatment options. With science as our foundation and empathy as our key guiding principle, colleagues become friends, managers become mentors, and with time, cancer becomes history.

Summary:
Initially reporting to Chief Medical and Development Officer, the Director/Sr. Director Translational Research is responsible for leading and managing core functions at Senti, responsible for clinical correlative analyses strategy and execution to support bench to bedside and back translation. The successful candidate will manage internal and external teams with capabilities for the development of models and analytics that help elucidate product activity, safety, pharmacokinetics and dynamics, and mechanism of action across Senti's oncology pipeline products. This individual will collaborate closely with Senti's discovery, preclinical research, process development, and clinical development groups to integrate translational research into the overall goals of furthering the company's pipeline products.
Responsibilities:

• Develop key methods for identification of clinical biomarkers and correlatives including pharmacokinetics, pharmacodynamics, companion diagnostics and immunogenicity assessment; ensure the appropriate collection, processing, management, and analysis of clinical samples
• Contribute to all relevant regulatory filings, and play a key role in shaping translational strategy
• Build, retain and motivate a superlative team of immunologists and cell biologists through recruitment, hiring and mentoring
• Participate in and lead cross-functional project teams
• Effectively communicate strategy, methodology, progress, and challenges to stakeholders and partners, including senior leadership and board of directors
• Lead activities to identify and manage industry and academic partners for cell therapy discovery and development studies
• Provide an external face to Senti through outside speaking engagements, and authorship of conference abstracts and journal publications
• Manage performance and development of entire staff

Qualifications:

• An MD and/or PhD in Biology, Immunology, Cell Biology, or related field
• 5+ years of industry experience, experience in academic groups supporting translational research efforts of clinical trials will be considered
• Highly knowledgeable in areas of immune cell biology, immuno-oncology, and cell therapy development
• Demonstrated expertise in cell therapy or immuno-oncology pharmacology and familiarity with regulatory expectations for Investigational New Drugs
• Ability to relate fundamental biological research to its application in the clinic
• Familiarity with current immunological, molecular, cellular, and genomic techniques, and biocomputational approaches
• Familiarity with basic pharmacokinetic principles
• Experience working on clinical stage programs with companion diagnostics and/or cell therapies preferred
• Excellent written, verbal, interpersonal, and leadership skills
• Track record of publications in key biology journals along with excellent presentation record in the field of immunology and immune-oncology
• Broad reputation within the scientific community
• Demonstrated passion for science and patients
• Requires independence, self-motivation, and high energy
• Flexibility to be able to change direction and grow as required in order to evolve the scientific direction of the company
• Strong scientific leadership experience, including experience leading multi-disciplinary

Salary and Benefits:

• Base pay and stock options to be determined based on application qualifications with the aim of being competitive with similar roles in the area
• Significant growth opportunity as the company expands
• Empathetic, supportive and collaborative colleagues and work environment

Senti Bio is a publicly traded (Nasdaq: SNTI) gene circuit company headquartered in South San Francisco. Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases using novel and unprecedented approaches.

We are committed to an inclusive and diverse Senti Bio. We believe that different perspectives lead to better ideas, and better ideas allow us to better understand the needs and interests of our diverse Senti Team. We welcome people of different backgrounds, experiences, abilities and perspectives and are an equal opportunity employer.