Research Associate / Senior Research Associate: stem cells and tissue regeneration
- Employer
- University of Bristol
- Location
- Bristol, United Kingdom
- Salary
- £35,333 - £39,745
- Closing date
- Oct 30, 2022
View more
- Sector
- Pharmaceutical, Business Development
- Hours
- Full Time
- Organization Type
- University and College
- Jobseeker Type
- Academic (e.g. 'Lecturer')
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The role
We are looking for a passionate, intellectually curious, and creative postdoctoral Research Associate / Senior Research Associate with a strong interest in stem cells and tissue regeneration to join our lab.
The Patel lab at the University of Bristol studies how tissues regenerate themselves after damage.
To understand this process, we use the adult Drosophila intestine (midgut), which has many similarities to our own intestine. Upon injury, the adult fly midgut regenerates itself by replacing lost cells via rapid intestinal stem cell (ISC) proliferation. One potential mechanism that may govern how midguts sense and respond to tissue damage is the production of reactive oxygen species (ROS), which play an essential role in whole body, appendage, and tissue regeneration in various organisms. Likewise, in adult fly midguts, ROS production also promotes ISC-mediated regeneration. Damage activates ROS-mediated Ask1-p38 stress signalling in enterocyes, which in turn stimulates production of an ISC mitogen (Patel, 2019; PMID:31554796). This mechanism, however, only partially accounts for how ROS promote midgut regeneration.
What will you be doing?
You will use genetics, transcriptomics, light microscopy and flow cytometry to further determine how damaged midguts respond to ROS and how ROS promote adult fly midgut regeneration. We have established several exciting projects making it an exciting time to join our lab. Your work will have far-reaching impact on our understanding of regeneration in many contexts and may help develop therapies for tissue regeneration, inflammatory diseases and cancer.
Our lab is generously funded by the Wellcome Trust, and you will have access to top-notch core facilities ( e.g., transcriptomics, flow cytometry and imaging) for your work, travel funds to attend conferences and access to staff development courses.
You should apply if
Applicants should have a PhD (awarded or soon-to-be awarded) in life sciences or in a related subject. Expertise with Drosophila is a plus but not essential.
To apply, please provide your CV and a cover letter (2 pages max), which includes: a) a description of your most important research contributions, why your research is important and what impact it has had, b) a statement of your research interests and career aspirations and c) an explanation of why you think our lab is the best environment for your career development.
The full-time appointment is available immediately (flexible start) and will be initially for 2 years with the possibility of extension for 1 or more years.
Non-UK candidates will be supported to obtain endorsement for a Global Talent Visa. Information about reimbursement of immigration and relocation costs can be found at: http://www.bristol.ac.uk/jobs/relocation-support . The grant will cover the Immigration Health Surcharge associated with applying for a visa.
We welcome applications from around the world and from under-represented individuals in science.
Starting salary: £35,333- £44,737, approx. £2,310-£2,840 (2670-3250€) take home/month). We also offer a generous pension scheme and value flexible working.
For more information, visit www.gutstresslab.org . Twitter:@gutstresslab. For informal enquiries please contact Dr Parthive Patel, p.patel@bristol.ac.uk
The city of Bristol offers a high quality of life and is often ranked the best place to live in the UK.
We seek to attract, develop, and retain individuals from the widest possible talent pool and the broadest possible range of backgrounds. We are committed to building an inclusive working environment where all colleagues can thrive and reach their full potential. We particularly welcome applications from Black African, Black Caribbean and other minority ethnic groups, as they are currently under-represented across our university.
Available documents
We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.
We are looking for a passionate, intellectually curious, and creative postdoctoral Research Associate / Senior Research Associate with a strong interest in stem cells and tissue regeneration to join our lab.
The Patel lab at the University of Bristol studies how tissues regenerate themselves after damage.
To understand this process, we use the adult Drosophila intestine (midgut), which has many similarities to our own intestine. Upon injury, the adult fly midgut regenerates itself by replacing lost cells via rapid intestinal stem cell (ISC) proliferation. One potential mechanism that may govern how midguts sense and respond to tissue damage is the production of reactive oxygen species (ROS), which play an essential role in whole body, appendage, and tissue regeneration in various organisms. Likewise, in adult fly midguts, ROS production also promotes ISC-mediated regeneration. Damage activates ROS-mediated Ask1-p38 stress signalling in enterocyes, which in turn stimulates production of an ISC mitogen (Patel, 2019; PMID:31554796). This mechanism, however, only partially accounts for how ROS promote midgut regeneration.
What will you be doing?
You will use genetics, transcriptomics, light microscopy and flow cytometry to further determine how damaged midguts respond to ROS and how ROS promote adult fly midgut regeneration. We have established several exciting projects making it an exciting time to join our lab. Your work will have far-reaching impact on our understanding of regeneration in many contexts and may help develop therapies for tissue regeneration, inflammatory diseases and cancer.
Our lab is generously funded by the Wellcome Trust, and you will have access to top-notch core facilities ( e.g., transcriptomics, flow cytometry and imaging) for your work, travel funds to attend conferences and access to staff development courses.
You should apply if
Applicants should have a PhD (awarded or soon-to-be awarded) in life sciences or in a related subject. Expertise with Drosophila is a plus but not essential.
To apply, please provide your CV and a cover letter (2 pages max), which includes: a) a description of your most important research contributions, why your research is important and what impact it has had, b) a statement of your research interests and career aspirations and c) an explanation of why you think our lab is the best environment for your career development.
The full-time appointment is available immediately (flexible start) and will be initially for 2 years with the possibility of extension for 1 or more years.
Non-UK candidates will be supported to obtain endorsement for a Global Talent Visa. Information about reimbursement of immigration and relocation costs can be found at: http://www.bristol.ac.uk/jobs/relocation-support . The grant will cover the Immigration Health Surcharge associated with applying for a visa.
We welcome applications from around the world and from under-represented individuals in science.
Starting salary: £35,333- £44,737, approx. £2,310-£2,840 (2670-3250€) take home/month). We also offer a generous pension scheme and value flexible working.
For more information, visit www.gutstresslab.org . Twitter:@gutstresslab. For informal enquiries please contact Dr Parthive Patel, p.patel@bristol.ac.uk
The city of Bristol offers a high quality of life and is often ranked the best place to live in the UK.
We seek to attract, develop, and retain individuals from the widest possible talent pool and the broadest possible range of backgrounds. We are committed to building an inclusive working environment where all colleagues can thrive and reach their full potential. We particularly welcome applications from Black African, Black Caribbean and other minority ethnic groups, as they are currently under-represented across our university.
Available documents
- CMM Further Particulars.pdf
- ACAD106359 - RA SRA - Job Description.pdf
We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.
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