The Miller Laboratory at the University of Virginia (millerlab.org) seeks a research scientist with a background in molecular biology or genetics to apply functional genomic analyses to investigate inherited vascular diseases and cardiomyopathies. Available projects include the application of single-nucleus (e.g. snRNA-seq, snATAC-seq, snCUT&Tag) and spatial (spatial transcriptomics, MERFISH, and proteomics) genomic analyses of healthy and diseased subjects of ancestrally diverse backgrounds. Some of the specific goals of this work are to: 1) optimize scalable single-nucleus and spatial genomic technologies for fresh and archived human biospecimens, 2) apply targeted and systematic genome engineering approaches to perturb candidate regulatory elements or genes in relevant cellular models, and 3) work with collaborators to develop and optimize phenotypic screens for genetic and drug perturbations. There will also be opportunities to develop bioinformatics and computational skills through collaborations on multiple internal and external projects.
The candidate will have access to a broad range of cutting edge wet-lab and computing resources, and will be exposed to a stimulating, multi-disciplinary and inclusive environment in the Center for Public Health Genomics (CPHG). This work will involve close collaborations with other CPHG labs to broaden training in both wet lab and computational biology skills. The candidate will also benefit from strong collaborations with faculty members in the Robert M. Berne Cardiovascular Research Center and Departments of Biomedical Engineering and Biochemistry and Molecular Genetics.
* PhD in the life sciences (e.g. molecular biology, genetics, or related field) required in hand by appointment start date.
* Strong working knowledge of biomedical fields, human physiology/disease, cell biology and signaling.
* Excellent written and verbal communication skills are required, as is the ability to work in a cross-functional team.
* Experience in human genetics or functional genomics is preferred.
* Some experience in bioinformatics or computational biology is preferred but not required.
The University will perform background checks on all new hires prior to employment. A completed pre-employment health screen is required for this position prior to employment.
Please apply through Workday, and search for R0037208. Internal applicants must apply through their UVA Workday profile by searching 'Find Jobs.' Complete an application online with the following documents:
* Cover letter
* Contact information for 3 references
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