Senior Associate Scientist, Virus Production Assay

Pearl River, New York
Closing date
Feb 5, 2023

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Science, Pharmaceutical, Supply Chain, Quality Assurance
Full Time
Organization Type
Jobseeker Type

You will join the Early Bioprocess Development (EBPD) effort to optimize and scale up virus production from mammalian cells to support vaccine development and clinical testing. Your primary responsibility is to produce a variety of viruses including BSL-3 level with decent titer and consistency at large scale using different vessels and technology. You will join a team to do production runs for different viruses with quality and lightning speed to meet timelines for different vaccine projects. Your work will emphasize on developing and implementing assays for in process samples. You will also collaborate with analytical team to generate QC report; keep batch record and QC documentation for different virus batches.

  • Join a team of scientists to produce different types of viruses with high titer and consistency at large scale using different host cells and vessels such as disposable bioreactors, wavebags, iCellis, CelCradle, cell factory, etc. to support viral vaccine development and clinical testing
  • Develop fast and high throughput in process assays such as molecular, biochemical, biophysical, or biological assays to characterize and improve virus product and upstream process
  • Optimize cell culture and virus production using automatic bioreactors such as AMBR250 with DOE principle which focuses on characterization, scale-up, and demonstration of process robustness
  • Produce viruses in both BSL-2 and BSL-3 level using either suspension cells or adherent cells
  • Purify, aliquot and curate viruses using different technologies for clinical testing
  • Generate and keep track of batch records for virus production runs
  • Keep track of virus QC reports, seed, passage history, sequence variation and other critical information
  • Maintain host cell culture and virus seed for different virus production runs
  • Collaborate with colleagues within EBPD including Upstream process development, Purification, Analytical, and Formulation Development groups
  • Evaluation and implementation of new technologies to improve virus production
  • Perform timely notebook entries and review for completed experiments.


Must Have
  • MS degree in Virology, Chemical Engineering, Microbiology, Immunology, Cell Biology, or other related discipline with some related virus production experience, BS degree with a minimum of 3 years related virus production experience in academia, a biotech and/or a pharmaceutical environment
  • Hands-on experience in mammalian cell culture using different vessels such as bioreactors, wavebags, iCellis etc.
  • Good sterility skills
  • Eager and fast learner

Nice to Have
  • Experience in both suspension and adherent cell culture for virus production
  • Experience working with different types and strains of viruses
  • Experience to design experiments to optimize mammalian cell culture and virus production in bioreactors based on DOE principle
  • Experience with disposable bioreactor/AMBR/Perfusion/iCELLis/continuous processing is a plus
  • Experience in virus purification and analytics such as UF/TFF, ultracentrifugation, chromatography, HA assay, plaque assay, TCID/50, FFA, qPCR, flowvirometry, etc.
  • BSL-3 lab experience and related regulatory knowledge such as GMP manufacturing considerations are preferred


The ability to make aseptic transfers and perform the relevant laboratory functions.

Mental requirements are a detailed understanding of the scientific subject matter, an ability to make scientific judgments and an ability to perform complex data analysis.


Works irregular hours (weekends and outside of 9-5 format) as experiments warrant
\nRelocation support available\n
Work Location Assignment: On Premise

Relocation assistance may be available based on business needs and/or eligibility.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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