Senior Research Assistant

Case Western Reserve University
Westlake, OH
Closing date
Feb 1, 2023

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Organization Type
Salary Grade
Salary Grade 12 for staff working 40 hours per week
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Job Description

Working under limited supervision, the Research Assistant 3 will coordinate research work supported by the NIH grant that focuses on identifying a new therapy for Alzheimer's disease. This position will work with animals and purified proteins.

  1. Coordinate laboratory/ research activities. Conduct pharmacologic treatment and maintenance of mouse colonies of the specified sizes; Isolate mouse tissues and assess them for sterol content, protein expression by Western blots, and gene expression by qRT-PCR. Express in E. coli and purify recombinant proteins. (50%)
  2. Work closely with the principal investigator and discuss on a daily basis the progress of current assignments. (7%)
  3. Carry out complex research assignments of a non-routine nature. Conduct preliminary analysis of the omics data. (10%)
  4. Devise new protocols and techniques for research projects involving a high degree of skill and training. Develop protocols for Western blot and qRT-PCR for the identification of a new protein and gene target. (7%)
  5. Evaluate adequacy of techniques; study and test new procedures and analyzes data. Perform data analysis for sterol quantifications, Western blots, and qRT-PCR. (7%)
  6. May supervise students and technicians. Train new staff regarding standard laboratory policies as well as basic laboratory techniques. (7%)
  7. May co-author research projects. Provide data to the principal investigator for sponsor progress reports, manuscripts, grants, and pilot applications. May monitor the laboratory budget. (7%)


Perform other duties as assigned. (5%)


Department: Daily contact with supervisor to discuss research and maintain workflow.

University: Occasional contact with other departments to share information.

External: Limited or no contact with vendors to exchange information.

Students: Contact with student employees to exchange information.


May supervise students and technicians.


Experience: 3 to 5 years of related experience required.

Education/Licensing: Bachelor of Science degree in biology or biochemistry is required.

  1. Has knowledge of commonly-used biological/biochemical/molecular biology concepts, laboratory practices, and procedures within biomedical field.
  2. Relies on instructions and pre-established guidelines to perform the functions of the job.
  3. Previous experience working with animals preferred.
  4. Must demonstrate compliance with Case Western Reserve University animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines.
  5. Must demonstrate compassion for animals within Case Western Reserve University facilities and dedication to the Animal Resource Center's mission. Must handle animals with care and respect at all times.
  6. Ability to operate laboratory equipment.
  7. Ability to meet consistent attendance.
  8. Ability to interact with colleagues and supervisors face to face.


General laboratory environment. May have exposure to hazards. Personal protective equipment, including lab coat, gloves and goggles, will be provided to limit exposure to hazards. This position is not eligible for the staff hybrid work program.

Case Western Reserve University's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals" appropriate Federal Animal Welfare Regulations, and the Public Health Service "Policy on the Humane Care and Use of Laboratory Animals." This position, and all animal research personnel, are subject to internal compliance to Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.

Diversity Statement
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

Reasonable Accommodations
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216-368-3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

COVID Vaccination
Case Western Reserve University has implemented a COVID Vaccination policy requiring evidence of COVID-19 vaccination for all students, faculty and staff with an on-campus presence. Religious and medical exemptions may be provided in accordance with applicable federal and state laws. For more information go to: Applicants may contact the Office of Equity at 216-368-3066 / for information regarding religious or medical exemptions as an accommodation.

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