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Principal Scientist, Neutralization Assay Scientist, Vaccines

Employer
Pfizer
Location
Pearl River, New York
Salary
Competitive
Closing date
Jan 28, 2023

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Sector
Science, Pharmaceutical
Hours
Full Time
Organization Type
Corporate
Jobseeker Type
Professional
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Pfizer Vaccine Research and Development

Pfizer's Vaccine Research and Development organization has been at the forefront of making history and improving human health - including creating some of the most complex and most sophisticated vaccines in the world, designed to tackle a wide range of infectious diseases of large unmet medical needs in people of all ages.

Role Summary

The High-throughput Clinical Immunoassays & Diagnostics (HCID) group within Pfizer Vaccines Research and Development is seeking a biologist with experience designing and trouble-shooting neutralization and biofunctional assays. As a Principal Scientist in the Neutralization Assay Group, the individual will be responsible primarily for generating high-quality biofunctional data in a regulated laboratory setting to support Pfizer's Phase 3 vaccine programs. This is a leadership role; the individual will be a senior member of the Neutralization Assay Group. Management responsibilities include managing a small team of laboratory scientists. As an integral member of this dynamic team, the incumbent must have a strong work ethic and be highly collaborative with group members. All work is to be done in a compliant manner according to relevant SOP and GLP guidelines, when required. The individual will author and review documentation to support the life cycle of the assay, including reagent qualification reports, responses with regulatory agencies, and internal and external presentations. The responsibilities also include reviewing clinical data and quality control data to monitor assay performance. As an expert, you will use your scientific acumen to validate biofunctional assays and address specific project requirements. Examples of collaboration efforts across multidisciplinary teams include Clinical & Diagnostic Assay Development, Cell Culture Team, Automation Group, Project Management, Quality Assurance, Research Informatics, and Statistics, as well as appropriate partner lines.

Role Responsibilities

  • Manage a viral or bacterial assay to support late-stage clinical testing, including managing a team of scientists to execute project goals and deliver compliant results according to program timelines
  • Design strategy for the execution of clinical testing to meet program timelines
  • Lead a team of junior scientists to execute project goals
  • Author and review documentation supporting the life cycle of the assay, including assay test methods, reagent qualifications, and other supportive documentation
  • Manage the preparation and qualification of new reagents
  • Perform experiments related to the optimization of biofunctional assays
  • Support ongoing clinical testing, including troubleshooting technical issues andaddressing queries from regulatory agencies
  • Provide scientific input on experimental design and data analysis
  • Supervise activities of direct reports, provide scientific leadership within the neutralization assay group, and foster teamwork, trust, and coaching among team members
  • Provide scientific strategy, analyze experimental data, draw conclusions, and propose future research plans
  • Communicate experimental results at team meetings with group members and senior management
  • Promote the use of novel experimental approaches within therapeutic area; routinely investigate/create innovative processes, hypotheses, and methodologies.
  • Stay current on scientific and technical literature plus attend relevant scientific meetings to apply new technologies and/or scientific principles
  • Participate and organize cross-functional team meetings


Qualifications and Basic Qualifications

Must-Have

  • MS with 10+ years relevant industry experience, or a PhD scientist with post-doctoral experience contributing to 4+ years of experience
  • Strong background in immunology, microbiology, virology, and/or bacteriology is essential
  • Familiarity with the process of bio-functional assay validation preferred, but not required
  • Experience working in laboratories operating under GLP guidelines, including SOPs, instrument IOQ/PQ, and good documentation practices
  • Demonstrated leadership ability through project management and mentoring
  • Proven delivery of objectives in a complex matrix environment
  • Ability to thrive in fast-paced, changing environment
  • Excellent verbal and written communication skills


Nice-to-Have

  • Classic virology, immunology, or microbiology expertise
  • Experience with laboratory automation, including Hamilton automated liquid handling workstations
  • Managerial experience, preferably in a commercial research and development setting with 3-5 direct reports
  • Experience within an industry setting, including a start-up company, or mid-size biotech/pharma


NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
  • This position may require occasional weekend and evening work to meet critical business timelines.
  • This position may require occasional travel between Pfizer sites and other business-related travel.
\nRelocation support available\n
Work Location Assignment: On Premise

Relocation assistance may be available based on business needs and/or eligibility.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
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