Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.
Are you an expert in targeted proteomics or protein LCMS bioanalysis and interested in contributing to transformative mRNA/LNP and biotherapeutics sciences? Join us for this exciting opportunity in the Biomeasures LCMS group in Pfizer Andover. The role will primarily develop protein mass spectrometry and targeted proteomics assays to measure concentrations and turnover of targets of biotherapeutics in a variety of biological matrices as well as transgene protein expression from mRNA-LNP therapies. The successful applicant will apply sample preparation and enrichment techniques including protein and peptide immunoaffinity in conjunction with LCMS-based detection using high resolution and triple quadrupole MS. The measured parameters from preclinical studies or human specimens are input parameters to mechanistic models supporting target evaluation, dose, or efficacy projections. The successful candidate will join a state-of-the-art laboratory with deep expertise in protein quantification by mass spectrometry and is expected to build strong collaborative partnerships, both within and outside the group. This position requires strong bioanalytical expertise, solid background in protein biochemistry, expertise in immunoanalytical procedures and triple quadrupole and high-resolution quantitative mass spectrometry. This position will work in project teams and interacts closely with the full spectrum of team members including modelling & simulation experts, project leads, biologists, and protein engineers.
• Responsible for the development, qualification and implementation of transgene protein, target biomeasure and pharmacodynamic biomarker assays using mass spectrometry in support of discovery and translational projects.
• As a strong collaborator and based on demonstrated project impact, develop deep partnerships in a matrix environment, influencing project strategies and translating project needs into fit-for-purpose assays.
• Participate or lead in technology development and implementation by exploring novel concepts and innovative workflows to expand the group's biomarker bioanalytical capabilities.
• Participate in all phases of mass spectrometry laboratory operations including technology evaluations, the development of sample preparation and separation methods, data analysis, interpretation, reporting and follow up discussions with the project teams on utilizing the data in appropriate decision making.
• Ensure all tasks and responsibilities are carried out according to scientific and ethical standards e.g. responsible for electronic notebook record keeping; QC and peer review of data and reports.
•Qualified applicants hold a Ph.D. and have post-doctoral experience or related degree with equivalent years of experience, ideally mostly in industry.
•Expertise in development, characterization, and implementation of biomarker assays based on quantitative protein mass spectrometry for drug development.
•Experience and knowledge in operation of modern triple quadrupole and ion trap/orbitrap mass spectrometers and associated control and data analysis software systems.
•Knowledge and application of complex sample preparation methodologies as applied to quantitative protein mass spectrometry workflows techniques including immuno-analytical techniques and tissue preparation/tissue bioanalysis.
•Good understanding of protein biochemistry.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
•Lab based position requiring to perform all typical laboratory related activities
•Based in Andover
•Occasional travel to Cambridge (Kendal Square) is required, depending on project needs
Work Location Assignment:On Premise
Relocation assistance may be available based on business needs and/or eligibility.
Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Research and Development