Research Associate II - CAR T Cell Therapy

City of Hope
Duarte, CA
Closing date
Jan 31, 2023

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Science, Life Sciences, Cell and Molecular Biology, Pharmaceutical, Clinical Research Associate
Organization Type
About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope's translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope's specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation's "Best Hospitals" in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope's commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary:

Under general supervision of the Principal Investigator, or designee, the Research Associate II (RAII) directs the work of a laboratory or undertakes research projects in collaboration with academic supervisor, making innovative contributions pertaining to laboratory procedures which may not change the course of an investigation but do indicate significant independent contribution beyond the RA I level. RAII typically consults with the academic supervisor on the scope and plan of approach to a research project; reads abstracts and articles; organize and plan techniques; plan and assign the work of at least one lab staff advising on problems they are unable to solve; contribute original ideas to the laboratory research; standardize new techniques and train staff on these techniques; perform specialized procedures and prepare written reports of laboratory experimental methods.

This is a fast-paced lab involved in cutting-edge technology, research, and clinical immunotherapeutic programs. We will train new personnel in project-specific techniques and procedures. The candidate must be able to work in a collaborative team environment and participate in data presentation during lab meetings.

Key Responsibilities:

* Tissue culture including application of aseptic techniques for media compounding, passaging, maintenance, and cryopreservation of cell cultures (e.g., T cell lines).
* Genetic modification, cloning, and characterization of T cell and tumor cell lines.
* Performance of T cell functional assays (e.g., cytotoxicity and cytokine production assays).
* Mouse handling for I.V. and I.P injections, bioluminescent imaging and tissue harvesting/preparation for immunohistochemistry and flow cytometric analysis.
* Aid in the training of new personnel including graduate students, summer students, and collaborators.
* Assisting in revising/maintaining lab protocols.
* Providing routine lab support and maintenance activities in the spirit of good laboratory practices (GLP).
* Meticulous attention to detail and accuracy in lab work as well as accurate record keeping, and lab documentation is a must.

Basic education, experience and skills required for consideration:

* Bachelor's degree. Master's degree preferred.
* Two years related research/ laboratory experience with a Bachelor's degree or one year related research/ laboratory experience with a Master's degree.

Preferred education experience and skills:

* Coursework and/or hands-on experience in cellular immunology and standard good laboratory practices (GLP) desired.
* Priority will be given to candidates with previous experience in tissue culture, flow cytometry, lentiviral transduction, and/or mouse handling.

Additional Information:

* The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate's experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.
* As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.
* See the lab web page for an overview of research interests at:
* Work hours may vary.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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